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10.1016/j.ccr.2014.04.021 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.04.021 C4096698!4096698!24856585     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2014 ; 25 (6): 735-47 Nephropedia Template TP {{tp|p=24856585|t=2014. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma |pdf=|usr=}}{{24856585}} gab.com Text Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24856585 #FOAvip Sonic hedgehog (Shh), a soluble ligand overexpres sed by neoplastic cells in pancreatic ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma. To better understand its role in malignant progression, we deleted Shh in a well-defined mouse model of PDAC. As predicted, Shh-deficient tumors had reduced stromal content. Surprisingly, such tumors were more aggressive and exhibited undifferentiated histology, increased vascularity, and heightened proliferation ? features that were fully recapitulated in control mice treated with a Smoothened inhibitor. Furthermore, administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors, indicating that Hedgehog-driven stroma suppresses tumor growth in part by restraining tumor angiogenesis. Together, these data demonstrate that some components of the tumor stroma can act to restrain tumor growth. Twit Text FOAVip Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=24856585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24856585 #FOAvip English Wikipedia <ref>{{Cite pmid|24856585}}</ref> Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma #MMPMID24856585 Rhim AD; Oberstein PE; Thomas DH; Mirek ET; Palermo CF; Sastra SA; Dekleva EN; Saunders T; Becerra CP; Tattersall IW; Westphalen CB; Kitajewski J; Fernandez-Barrena MG; Fernandez-Zapico ME; Iacobuzzio-Donahue C; Olive KP; Stanger BZ Cancer Cell 2014[Jun]; 25 (6): 735-47 PMID24856585show ga Sonic hedgehog (Shh), a soluble ligand overexpres sed by neoplastic cells in pancreatic ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma. To better understand its role in malignant progression, we deleted Shh in a well-defined mouse model of PDAC. As predicted, Shh-deficient tumors had reduced stromal content. Surprisingly, such tumors were more aggressive and exhibited undifferentiated histology, increased vascularity, and heightened proliferation ? features that were fully recapitulated in control mice treated with a Smoothened inhibitor. Furthermore, administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors, indicating that Hedgehog-driven stroma suppresses tumor growth in part by restraining tumor angiogenesis. Together, these data demonstrate that some components of the tumor stroma can act to restrain tumor growth. äStromal elements act to restrain, rather than support, pancreatic duct(epmc).pdf DeepDyve Pubget Overpricing