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10.1161/CIRCRESAHA.115.301146

http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.115.301146
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C4096686!4096686!24951762
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suck abstract from ncbi


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pmid24951762      Circ+Res 2014 ; 115 (1): 115-30
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  • Pulmonary Arterial Hypertension: The Clinical Syndrome #MMPMID24951762
  • Lai YC; Potoka KC; Champion HC; Mora AL; Gladwin MT
  • Circ Res 2014[Jun]; 115 (1): 115-30 PMID24951762show ga
  • Pulmonary arterial hypertension (PAH) is a progressive disorder in which endothelial dysfunction and vascular remodeling obstruct small pulmonary arteries, resulting in increased pulmonary vascular resistance and pulmonary pressures. This leads to reduced cardiac output, right heart failure, and ultimately death. In this review, we attempt to answer some important questions commonly asked by patients diagnosed with PAH pertaining to the disease, and aim to provide an explanation in terms of classification, diagnosis, pathophysiology, genetic etiologies, demographics, and prognostic factors. Furthermore, important molecular pathways that are central to the pathogenesis of PAH are reviewed, including nitric oxide, prostacyclin, endothelin-1, reactive oxygen species, and endothelial and smooth muscle proliferation.
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