Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.matbio.2014.01.002 http://scihub22266oqcxt.onion/10.1016/j.matbio.2014.01.002 C4096433!4096433 !24418252     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24418252 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Matrix+Biol 2014 ; 37 (ä): 92-101 Nephropedia Template TP {{tp|p=24418252 |t=2014. Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease |pdf=|usr=}}{{24418252 }} gab.com Text Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease JO: Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=24418252 #FOAvip Cardiovascular homeostasis and health is maintained through the balanced interactions of cardiac generated blood flow and cross-talk between the cellular components that comprise blood vessels. Central to this cross-talk is endothelial generated nitric oxide (NO) that stimulates relaxation of the contractile vascular smooth muscle (VSMC) layer of blood vessels. In cardiovascular disease this balanced interaction is disrupted and NO signaling is lost. Work over the last several years indicates that regulation of NO is much more complex than previously believed. It is now apparent that the secreted protein thrombospondin-1 (TSP1), that is upregulated in cardiovascular disease and animal models of the same, on activating cell surface receptor CD47, redundantly inhibits NO production and NO signaling. This inhibitory event has implications for baseline and disease-related responses mediated by NO. Further work has identified that TSP1-CD47 signaling stimulates enzymatic reactive oxygen species (ROS) production to further limit blood flow and promote vascular disease. Herein consideration is given to the most recent discoveries in this regard which identify the TSP1-CD47 axis as a major proximate governor of cardiovascular health. Twit Text FOAVip Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease ????Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=24418252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24418252 #FOAvip English Wikipedia <ref>{{Cite pmid|24418252 }}</ref> Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease #MMPMID24418252 Rogers NM ; Sharifi-Sanjani M ; Csányi G ; Pagano PJ ; Isenberg JS Matrix Biol 2014[Jul]; 37 (ä): 92-101 PMID24418252 show ga Cardiovascular homeostasis and health is maintained through the balanced interactions of cardiac generated blood flow and cross-talk between the cellular components that comprise blood vessels. Central to this cross-talk is endothelial generated nitric oxide (NO) that stimulates relaxation of the contractile vascular smooth muscle (VSMC) layer of blood vessels. In cardiovascular disease this balanced interaction is disrupted and NO signaling is lost. Work over the last several years indicates that regulation of NO is much more complex than previously believed. It is now apparent that the secreted protein thrombospondin-1 (TSP1), that is upregulated in cardiovascular disease and animal models of the same, on activating cell surface receptor CD47, redundantly inhibits NO production and NO signaling. This inhibitory event has implications for baseline and disease-related responses mediated by NO. Further work has identified that TSP1-CD47 signaling stimulates enzymatic reactive oxygen species (ROS) production to further limit blood flow and promote vascular disease. Herein consideration is given to the most recent discoveries in this regard which identify the TSP1-CD47 axis as a major proximate governor of cardiovascular health. |CD47 Antigen/*metabolism/therapeutic use [MESH] |Cardiovascular Diseases/metabolism/*physiopathology [MESH] |Cyclic AMP/metabolism [MESH] |Cyclic GMP/metabolism [MESH] |Gene Expression Regulation/*physiology [MESH] |Humans [MESH] |Models, Biological [MESH] |Nitric Oxide/metabolism [MESH] |Regional Blood Flow/*physiology [MESH] |Signal Transduction/*physiology [MESH] |Thrombosis/*prevention & control [MESH] |Thrombospondin 1/*metabolism/therapeutic use [MESH]Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascula(epmc).pdf DeepDyve Pubget Overpricing