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10.1016/j.bbamcr.2014.04.019 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2014.04.019 C4096426!4096426 !24769209     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24769209 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2014 ; 1843 (9 ): 1839-50 Nephropedia Template TP {{tp|p=24769209 |t=2014. Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells |pdf=|usr=}}{{24769209 }} gab.com Text Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24769209 #FOAvip Cholesterol has been shown to promote cell proliferation/migration in many cells; however the mechanism(s) have not yet been fully identified. Here we demonstrate that cholesterol increases Ca(2+) entry via the TRPM7 channel, which promoted proliferation of prostate cells by inducing the activation of the AKT and/or the ERK pathway. Additionally, cholesterol mediated Ca(2+) entry induced calpain activity that showed a decrease in E-cadherin expression, which together could lead to migration of prostate cancer cells. An overexpression of TRPM7 significantly facilitated cholesterol dependent Ca(2+) entry, cell proliferation and tumor growth. Whereas, TRPM7 silencing or inhibition of cholesterol synthesis by statin showed a significant decrease in cholesterol-mediated activation of TRPM7, cell proliferation, and migration of prostate cancer cells. Consistent with these results, statin intake was inversely correlated with prostate cancer patients and increase in TRPM7 expression was observed in samples obtained from prostate cancer patients. Altogether, we provide evidence that cholesterol-mediated activation of TRPM7 is important for prostate cancer and have identified that TRPM7 could be essential for initiation and/or progression of prostate cancer. Twit Text FOAVip Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24769209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24769209 #FOAvip English Wikipedia <ref>{{Cite pmid|24769209 }}</ref> Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells #MMPMID24769209 Sun Y ; Sukumaran P ; Varma A ; Derry S ; Sahmoun AE ; Singh BB Biochim Biophys Acta 2014[Sep]; 1843 (9 ): 1839-50 PMID24769209 show ga Cholesterol has been shown to promote cell proliferation/migration in many cells; however the mechanism(s) have not yet been fully identified. Here we demonstrate that cholesterol increases Ca(2+) entry via the TRPM7 channel, which promoted proliferation of prostate cells by inducing the activation of the AKT and/or the ERK pathway. Additionally, cholesterol mediated Ca(2+) entry induced calpain activity that showed a decrease in E-cadherin expression, which together could lead to migration of prostate cancer cells. An overexpression of TRPM7 significantly facilitated cholesterol dependent Ca(2+) entry, cell proliferation and tumor growth. Whereas, TRPM7 silencing or inhibition of cholesterol synthesis by statin showed a significant decrease in cholesterol-mediated activation of TRPM7, cell proliferation, and migration of prostate cancer cells. Consistent with these results, statin intake was inversely correlated with prostate cancer patients and increase in TRPM7 expression was observed in samples obtained from prostate cancer patients. Altogether, we provide evidence that cholesterol-mediated activation of TRPM7 is important for prostate cancer and have identified that TRPM7 could be essential for initiation and/or progression of prostate cancer. |Aged [MESH] |Calcium Signaling/drug effects [MESH] |Calcium/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Cholesterol/*pharmacology [MESH] |Demography [MESH] |Gene Knockout Techniques [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology [MESH] |Ion Channel Gating/drug effects [MESH] |Male [MESH] |Models, Biological [MESH] |Prostate/*metabolism/*pathology [MESH] |Prostatic Neoplasms/metabolism/pathology [MESH] |Protein Serine-Threonine Kinases [MESH]Cholesterol-induced activation of TRPM7 regulates cell proliferation, (epmc).pdf DeepDyve Pubget Overpricing