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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Child+Neurol 2014 ; 29 (12): 1685-91 Nephropedia Template TP
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Reproducibility of Detecting Silent Cerebral Infarcts in Pediatric Sickle Cell Anemia #MMPMID24309240
Liem RI; Liu J; Gordon MO; Vendt BA; McKinstry RC; Kraut MA; Strouse JJ; Ball WS; DeBaun MR
J Child Neurol 2014[Dec]; 29 (12): 1685-91 PMID24309240show ga
Detecting silent cerebral infarcts (SCI) on MRI in children with sickle cell anemia (SCA) is challenging, yet reproducibility of readings has not been examined in this population. We evaluated consensus rating, inter- and intra-grader agreement associated with detecting SCI on screening MRI in the Silent Infarct Transfusion (SIT) Trial. Three neuroradiologists provided consensus decisions for 1,073 MRIs. A random sample of 53 scans was re-analyzed in blinded fashion. Agreement between first and second consensus ratings was substantial (? = 0.70, p < 0.0001), as was overall inter-grader agreement (? = 0.76, p < 0.0001). In the test-retest sample, intra-grader agreement ranged from ? of 0.57 to 0.76. Consensus decisions were more concordant when MRIs contained more than one lesion and lesions were larger. We conclude that the routine use of MRI to screen for SCI in the research setting is reproducible in SCA and agreement among neuroradiologists is sufficient.