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10.1074/jbc.M114.550624

http://scihub22266oqcxt.onion/10.1074/jbc.M114.550624
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C4094069!4094069!24841199
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suck abstract from ncbi


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pmid24841199      J+Biol+Chem 2014 ; 289 (28): 19571-84
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  • Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome* #MMPMID24841199
  • Bracey NA; Gershkovich B; Chun J; Vilaysane A; Meijndert HC; Wright JR; Fedak PW; Beck PL; Muruve DA; Duff HJ
  • J Biol Chem 2014[Jul]; 289 (28): 19571-84 PMID24841199show ga
  • Background: NLRP3 is a pattern recognition receptor that regulates inflammatory cytokine processing through the inflammasome.Results: In cardiac fibroblasts, NLRP3 promotes fibrotic signaling through a novel mechanism independent from cytokine release.Conclusion: NLRP3 displays inflammasome-independent pathways in cardiac fibroblasts and during fibrosis.Significance: NLRP3 represents a potential direct target in fibrotic heart disease and heart failure.
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