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10.1074/jbc.M114.570044

http://scihub22266oqcxt.onion/10.1074/jbc.M114.570044
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C4094041!4094041!24876382
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suck abstract from ncbi


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pmid24876382      J+Biol+Chem 2014 ; 289 (28): 19279-93
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  • Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion* #MMPMID24876382
  • Mattijssen F; Georgiadi A; Andasarie T; Szalowska E; Zota A; Krones-Herzig A; Heier C; Ratman D; De Bosscher K; Qi L; Zechner R; Herzig S; Kersten S
  • J Biol Chem 2014[Jul]; 289 (28): 19279-93 PMID24876382show ga
  • Background: PPAR? is an important regulator of hepatic lipid metabolism via target gene regulation.Results: HILPDA is regulated by PPAR? via an upstream PPRE. Targeted overexpression of HILPDA increases hepatic triglyceride storage via reduction of TG secretion.Conclusion: HILPDA is a novel PPAR? target involved in hepatic triglyceride secretion.Significance: HILPDA might be a potential target in the treatment of non-alcoholic fatty liver disease.
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