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10.1074/jbc.M114.570044 http://scihub22266oqcxt.onion/10.1074/jbc.M114.570044 C4094041!4094041 !24876382     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24876382 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion |pdf=|usr=}}{{24876382 }} gab.com Text Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24876382 #FOAvip Peroxisome proliferator-activated receptors (PPARs) play major roles in the regulation of hepatic lipid metabolism through the control of numerous genes involved in processes such as lipid uptake and fatty acid oxidation. Here we identify hypoxia-inducible lipid droplet-associated (Hilpda/Hig2) as a novel PPAR target gene and demonstrate its involvement in hepatic lipid metabolism. Microarray analysis revealed that Hilpda is one of the most highly induced genes by the PPAR? agonist Wy14643 in mouse precision cut liver slices. Induction of Hilpda mRNA by Wy14643 was confirmed in mouse and human hepatocytes. Oral dosing with Wy14643 similarly induced Hilpda mRNA levels in livers of wild-type mice but not Ppara(-/-) mice. Transactivation studies and chromatin immunoprecipitation showed that Hilpda is a direct PPAR? target gene via a conserved PPAR response element located 1200 base pairs upstream of the transcription start site. Hepatic overexpression of HILPDA in mice via adeno-associated virus led to a 4-fold increase in liver triglyceride storage, without any changes in key genes involved in de novo lipogenesis, ?-oxidation, or lipolysis. Moreover, intracellular lipase activity was not affected by HILPDA overexpression. Strikingly, HILPDA overexpression significantly impaired hepatic triglyceride secretion. Taken together, our data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion. Twit Text FOAVip Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24876382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24876382 #FOAvip English Wikipedia <ref>{{Cite pmid|24876382 }}</ref> Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion #MMPMID24876382 Mattijssen F ; Georgiadi A ; Andasarie T ; Szalowska E ; Zota A ; Krones-Herzig A ; Heier C ; Ratman D ; De Bosscher K ; Qi L ; Zechner R ; Herzig S ; Kersten S J Biol Chem 2014[Jul]; 289 (28 ): 19279-93 PMID24876382 show ga Peroxisome proliferator-activated receptors (PPARs) play major roles in the regulation of hepatic lipid metabolism through the control of numerous genes involved in processes such as lipid uptake and fatty acid oxidation. Here we identify hypoxia-inducible lipid droplet-associated (Hilpda/Hig2) as a novel PPAR target gene and demonstrate its involvement in hepatic lipid metabolism. Microarray analysis revealed that Hilpda is one of the most highly induced genes by the PPAR? agonist Wy14643 in mouse precision cut liver slices. Induction of Hilpda mRNA by Wy14643 was confirmed in mouse and human hepatocytes. Oral dosing with Wy14643 similarly induced Hilpda mRNA levels in livers of wild-type mice but not Ppara(-/-) mice. Transactivation studies and chromatin immunoprecipitation showed that Hilpda is a direct PPAR? target gene via a conserved PPAR response element located 1200 base pairs upstream of the transcription start site. Hepatic overexpression of HILPDA in mice via adeno-associated virus led to a 4-fold increase in liver triglyceride storage, without any changes in key genes involved in de novo lipogenesis, ?-oxidation, or lipolysis. Moreover, intracellular lipase activity was not affected by HILPDA overexpression. Strikingly, HILPDA overexpression significantly impaired hepatic triglyceride secretion. Taken together, our data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion. |Animals [MESH] |Anticholesteremic Agents/pharmacology [MESH] |Cell Line [MESH] |Humans [MESH] |Lipogenesis/drug effects/*physiology [MESH] |Liver/cytology/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |PPAR alpha/genetics/*metabolism [MESH] |Pyrimidines/pharmacology [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Response Elements/physiology [MESH]Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxis(epmc).pdf DeepDyve Pubget Overpricing