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10.1182/blood-2014-01-550566 http://scihub22266oqcxt.onion/10.1182/blood-2014-01-550566 C4093684!4093684 !24797298     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24797298 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2014 ; 124 (2 ): 287-95 Nephropedia Template TP {{tp|p=24797298 |t=2014. Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality |pdf=|usr=}}{{24797298 }} gab.com Text Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=24797298 #FOAvip Whether the hematopoietic cell transplantation comorbidity index (HCT-CI) can provide prognostic information about development of acute graft-versus-host disease (GVHD) and subsequent mortality is unknown. Five institutions contributed information on 2985 patients given human leukocyte antigen-matched grafts to address this question. Proportional hazards models were used to estimate the hazards of acute GVHD and post-GVHD mortality after adjustment for known risk variables. Higher HCT-CI scores predicted increased risk of grades 3 to 4 acute GVHD (P < .0001 and c-statistic of 0.64), and tests of interaction suggested that this association was consistent among different conditioning intensities, donor types, and stem cell sources. Probabilities of grades 3 to 4 GVHD were 13%, 18%, and 24% for HCT-CI risk groups of 0, 1 to 4, and ?5. The HCT-CI was statistically significantly associated with mortality rates following diagnosis of grade 2 (hazard ratio [HR] = 1.24; P < .0001) or grades 3 to 4 acute GVHD (HR = 1.19; P < .0001). Patients with HCT-CI scores of ?3 who developed grades 3 to 4 acute GVHD had a 2.63-fold higher risk of mortality than those with scores of 0 to 2 and did not develop acute GVHD. Thus, pretransplant comorbidities are associated with the development and severity of acute GVHD and with post-GVHD mortality. The HCT-CI could be useful in designing trials for GVHD prevention and could inform expectations for GVHD treatment trials. Twit Text FOAVip Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=24797298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24797298 #FOAvip English Wikipedia <ref>{{Cite pmid|24797298 }}</ref> Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality #MMPMID24797298 Sorror ML ; Martin PJ ; Storb RF ; Bhatia S ; Maziarz RT ; Pulsipher MA ; Maris MB ; Davis C ; Deeg HJ ; Lee SJ ; Maloney DG ; Sandmaier BM ; Appelbaum FR ; Gooley TA Blood 2014[Jul]; 124 (2 ): 287-95 PMID24797298 show ga Whether the hematopoietic cell transplantation comorbidity index (HCT-CI) can provide prognostic information about development of acute graft-versus-host disease (GVHD) and subsequent mortality is unknown. Five institutions contributed information on 2985 patients given human leukocyte antigen-matched grafts to address this question. Proportional hazards models were used to estimate the hazards of acute GVHD and post-GVHD mortality after adjustment for known risk variables. Higher HCT-CI scores predicted increased risk of grades 3 to 4 acute GVHD (P < .0001 and c-statistic of 0.64), and tests of interaction suggested that this association was consistent among different conditioning intensities, donor types, and stem cell sources. Probabilities of grades 3 to 4 GVHD were 13%, 18%, and 24% for HCT-CI risk groups of 0, 1 to 4, and ?5. The HCT-CI was statistically significantly associated with mortality rates following diagnosis of grade 2 (hazard ratio [HR] = 1.24; P < .0001) or grades 3 to 4 acute GVHD (HR = 1.19; P < .0001). Patients with HCT-CI scores of ?3 who developed grades 3 to 4 acute GVHD had a 2.63-fold higher risk of mortality than those with scores of 0 to 2 and did not develop acute GVHD. Thus, pretransplant comorbidities are associated with the development and severity of acute GVHD and with post-GVHD mortality. The HCT-CI could be useful in designing trials for GVHD prevention and could inform expectations for GVHD treatment trials. |*Hematopoietic Stem Cell Transplantation/adverse effects/statistics & numerical data [MESH] |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Child [MESH] |Child, Preschool [MESH] |Comorbidity [MESH] |Graft vs Host Disease/*diagnosis/etiology/*mortality [MESH] |Hematologic Diseases/*diagnosis/*mortality/*therapy [MESH] |Humans [MESH] |Infant [MESH] |Infant, Newborn [MESH] |Middle Aged [MESH] |Prognosis [MESH] |Retrospective Studies [MESH] |Transplantation Conditioning/adverse effects/methods/mortality [MESH]Pretransplant comorbidities predict severity of acute graft-versus-hos(epmc).pdf DeepDyve Pubget Overpricing