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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Pediatr+Pharmacol+Ther
2014 ; 19
(2
): 91-7
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English Wikipedia
Use of intravenous magnesium sulfate for the treatment of an acute asthma
exacerbation in pediatric patients
#MMPMID25024668
Kokotajlo S
; Degnan L
; Meyers R
; Siu A
; Robinson C
J Pediatr Pharmacol Ther
2014[Apr]; 19
(2
): 91-7
PMID25024668
show ga
OBJECTIVES: The standard of care for treatment of an asthma exacerbation includes
oxygen, inhaled short-acting bronchodilators, and systemic corticosteroids;
adjunctive therapies, such as intravenous magnesium sulfate, can be used for
patients who are having life-threatening exacerbations. The purpose of this study
was to analyze the prescribing patterns as well as the safety of intravenous
magnesium sulfate for the treatment of acute asthma exacerbations in pediatric
patients across multiple hospitals in New Jersey. METHODS: This retrospective
chart review was conducted at 4 medical centers in New Jersey on patients who
presented to the emergency department between January 1, 2010, and December 31,
2010. RESULTS: Fifty-three patients were included in the study. In the emergency
department, 98% of patients received inhaled albuterol plus ipratropium and 85%
received systemic corticosteroids before intravenous magnesium sulfate
administration. The median dose of magnesium sulfate was 40 mg/kg with a median
time of administration of 20 minutes. One patient experienced hypotension that
was thought to be related to magnesium sulfate administration. CONCLUSIONS: This
study demonstrates that weight-based dosage, as well as time of administration of
magnesium sulfate for pediatric patients with an acute asthma exacerbation,
varies across different institutions in New Jersey. Magnesium sulfate use was
safe in this patient population.
free
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