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10.1021/ja504617n http://scihub22266oqcxt.onion/10.1021/ja504617n C4091270!4091270!24884988     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2014 ; 136 (26): 9484-90 Nephropedia Template TP {{tp|p=24884988|t=2014. The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity |pdf=|usr=}}{{24884988}} gab.com Text The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24884988 #FOAvip Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe?host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secretion systems, cellular capsule, pili), the role of the large cryptic secondary metabolome encoded within its genome has been largely unexplored for its importance to virulence. Herein we demonstrate that BP-encoded small-molecule biosynthesis is indispensible for in vivo BP pathogenicity. Promoter exchange experiments were used to induce high-level molecule production from two gene clusters (MPN and SYR) found to be essential for in vivo virulence. NMR structural characterization of these metabolites identified a new class of lipopeptide biosurfactants/biofilm modulators (the malleipeptins) and syrbactin-type proteasome inhibitors, both of which represent overlooked small-molecule virulence factors for BP. Disruption of Burkholderia virulence by inhibiting the biosynthesis of these small-molecule biosynthetic pathways may prove to be an effective strategy for developing novel melioidosis-specific therapeutics. Twit Text FOAVip The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24884988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24884988 #FOAvip English Wikipedia <ref>{{Cite pmid|24884988}}</ref> The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity #MMPMID24884988 Biggins JB; Kang HS; Ternei M; DeShazer D; Brady SF J Am Chem Soc 2014[Jul]; 136 (26): 9484-90 PMID24884988show ga Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe?host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secretion systems, cellular capsule, pili), the role of the large cryptic secondary metabolome encoded within its genome has been largely unexplored for its importance to virulence. Herein we demonstrate that BP-encoded small-molecule biosynthesis is indispensible for in vivo BP pathogenicity. Promoter exchange experiments were used to induce high-level molecule production from two gene clusters (MPN and SYR) found to be essential for in vivo virulence. NMR structural characterization of these metabolites identified a new class of lipopeptide biosurfactants/biofilm modulators (the malleipeptins) and syrbactin-type proteasome inhibitors, both of which represent overlooked small-molecule virulence factors for BP. Disruption of Burkholderia virulence by inhibiting the biosynthesis of these small-molecule biosynthetic pathways may prove to be an effective strategy for developing novel melioidosis-specific therapeutics. äThe Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pat(epmc).pdf DeepDyve Pubget Overpricing