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10.4161/auto.28769 http://scihub22266oqcxt.onion/10.4161/auto.28769 C4091176!4091176!24879161     free     free     free       Autophagy 2014 ; 10 (6): 1146-7 Nephropedia Template TP {{tp|p=24879161|t=2014. Autophagy side of MB21D1/cGAS DNA sensor |pdf=|usr=}}{{24879161}} gab.com Text Autophagy side of MB21D1/cGAS DNA sensor JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24879161 #FOAvip The MB21D1/cGAS (Mab-21 domain-containing 1/cyclic GMP-AMP [cGAMP] synthetase), acts as an intracellular pattern recognition receptor (PPR) to sense cytosolic pathogen DNAs and subsequently generates the second messenger cGAMP to initiate the TMEM173/STING pathway for interferon (IFN) production. Intriguingly, we have recently demonstrated crosstalk between the intracellular DNA sensing pathway and autophagy machinery by demonstrating a direct interaction between the MB21D1 DNA sensor and the BECN1/Beclin 1 autophagy protein. This interaction not only suppresses MB21D1 enzymatic activity to halt cGAMP production, but also enhances the autophagy-mediated degradation of cytosolic microbial DNAs. This demonstrates that MB21D1 is the molecular link between the intracellular DNA sensing pathway and the autophagy pathway, ultimately developing well-balanced immune responses against pathogens. Twit Text FOAVip Autophagy side of MB21D1/cGAS DNA sensor ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24879161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24879161 #FOAvip English Wikipedia <ref>{{Cite pmid|24879161}}</ref> Autophagy side of MB21D1/cGAS DNA sensor #MMPMID24879161 Liang Q; Seo GJ; Choi YJ; Ge J; Rodgers MA; Shi M; Jung JU Autophagy 2014[Jun]; 10 (6): 1146-7 PMID24879161show ga The MB21D1/cGAS (Mab-21 domain-containing 1/cyclic GMP-AMP [cGAMP] synthetase), acts as an intracellular pattern recognition receptor (PPR) to sense cytosolic pathogen DNAs and subsequently generates the second messenger cGAMP to initiate the TMEM173/STING pathway for interferon (IFN) production. Intriguingly, we have recently demonstrated crosstalk between the intracellular DNA sensing pathway and autophagy machinery by demonstrating a direct interaction between the MB21D1 DNA sensor and the BECN1/Beclin 1 autophagy protein. This interaction not only suppresses MB21D1 enzymatic activity to halt cGAMP production, but also enhances the autophagy-mediated degradation of cytosolic microbial DNAs. This demonstrates that MB21D1 is the molecular link between the intracellular DNA sensing pathway and the autophagy pathway, ultimately developing well-balanced immune responses against pathogens. äAutophagy side of MB21D1/cGAS DNA sensor (epmc).pdf DeepDyve Pubget Overpricing