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10.4161/auto.28615 http://scihub22266oqcxt.onion/10.4161/auto.28615 C4091171!4091171 !24879156     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24879156 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2014 ; 10 (6 ): 1105-19 Nephropedia Template TP {{tp|p=24879156 |t=2014. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria |pdf=|usr=}}{{24879156 }} gab.com Text BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24879156 #FOAvip The autophagy protein BECN1/Beclin 1 is known to play a central role in autophagosome formation and maturation. The results presented here demonstrate that BECN1 interacts with the Parkinson disease-related protein PARK2. This interaction does not require PARK2 translocation to mitochondria and occurs mostly in cytosol. However, our results suggest that BECN1 is involved in PARK2 translocation to mitochondria because loss of BECN1 inhibits CCCP- or PINK1 overexpression-induced PARK2 translocation. Our results also demonstrate that the observed PARK2-BECN1 interaction is functionally important. Measurements of the level of MFN2 (mitofusin 2), a PARK2 substrate, demonstrate that depletion of BECN1 prevents PARK2 translocation-induced MFN2 ubiquitination and loss. BECN1 depletion also rescues the MFN2 loss-induced suppression of mitochondrial fusion. In sum, our results demonstrate that BECN1 interacts with PARK2 and regulates PARK2 translocation to mitochondria as well as PARK2-induced mitophagy prior to autophagosome formation. Twit Text FOAVip BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24879156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24879156 #FOAvip English Wikipedia <ref>{{Cite pmid|24879156 }}</ref> BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria #MMPMID24879156 Choubey V ; Cagalinec M ; Liiv J ; Safiulina D ; Hickey MA ; Kuum M ; Liiv M ; Anwar T ; Eskelinen EL ; Kaasik A Autophagy 2014[Jun]; 10 (6 ): 1105-19 PMID24879156 show ga The autophagy protein BECN1/Beclin 1 is known to play a central role in autophagosome formation and maturation. The results presented here demonstrate that BECN1 interacts with the Parkinson disease-related protein PARK2. This interaction does not require PARK2 translocation to mitochondria and occurs mostly in cytosol. However, our results suggest that BECN1 is involved in PARK2 translocation to mitochondria because loss of BECN1 inhibits CCCP- or PINK1 overexpression-induced PARK2 translocation. Our results also demonstrate that the observed PARK2-BECN1 interaction is functionally important. Measurements of the level of MFN2 (mitofusin 2), a PARK2 substrate, demonstrate that depletion of BECN1 prevents PARK2 translocation-induced MFN2 ubiquitination and loss. BECN1 depletion also rescues the MFN2 loss-induced suppression of mitochondrial fusion. In sum, our results demonstrate that BECN1 interacts with PARK2 and regulates PARK2 translocation to mitochondria as well as PARK2-induced mitophagy prior to autophagosome formation. |Animals [MESH] |Apoptosis Regulatory Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Autophagy [MESH] |Beclin-1 [MESH] |Biological Transport, Active [MESH] |Cells, Cultured [MESH] |GTP Phosphohydrolases [MESH] |Gene Knockdown Techniques [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Mice [MESH] |Mitochondria/metabolism [MESH] |Mitochondrial Proteins/genetics/metabolism [MESH] |Mitophagy/*physiology [MESH] |Mutant Proteins/genetics/metabolism [MESH] |PC12 Cells [MESH] |Protein Kinases/genetics/metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Rats [MESH] |Recombinant Proteins/genetics/metabolism [MESH] |Ubiquitin-Protein Ligases/genetics/*metabolism [MESH]BECN1 is involved in the initiation of mitophagy: it facilitates PARK2(epmc).pdf DeepDyve Pubget Overpricing