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10.4161/auto.28103

http://scihub22266oqcxt.onion/10.4161/auto.28103
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C4091162!4091162!24561915
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suck abstract from ncbi


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pmid24561915      Autophagy 2014 ; 10 (4): 708-9
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  • A requirement for ER-derived COPII vesicles in phagophore initiation #MMPMID24561915
  • Wang J; Tan D; Cai Y; Reinisch KM; Walz T; Ferro-Novick S
  • Autophagy 2014[Apr]; 10 (4): 708-9 PMID24561915show ga
  • A major unanswered question in the field of autophagy is how the double-membrane phagophore is formed. As this membrane expands, it engulfs proteins and organelles that are destined for degradation and then seals to form an autophagosome. A growing consensus in the field is that a subdomain of the ER initiates formation of the phagophore. We show that ER-derived COPII-coated vesicles, which bud from a specialized domain of the ER called the ER exit site (ERES), are a source of this membrane. This finding will now pave the way for a biochemical description of the early steps of phagophore initiation.
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