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10.4161/auto.27955 http://scihub22266oqcxt.onion/10.4161/auto.27955 C4091158!4091158!24492492     free     free     free       Autophagy 2014 ; 10 (4): 699-701 Nephropedia Template TP {{tp|p=24492492|t=2014. NOX4 regulates autophagy during energy deprivation |pdf=|usr=}}{{24492492}} gab.com Text NOX4 regulates autophagy during energy deprivation JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24492492 #FOAvip NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress. NOX4 activity and protein levels are increased in the endoplasmic reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase of energy deprivation. NOX4-derived production of ROS in the ER is a critical event that activates autophagy through stimulation of the EIF2AK3/PERK-EIF2S1/eIF-2?-ATF4 pathway. NOX4-dependent autophagy is an important mechanism to preserve cellular energy and limit cell death in energy-deprived cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4 during cellular energy stress, our study dissects a novel signaling mechanism that regulates autophagy under this condition. Twit Text FOAVip NOX4 regulates autophagy during energy deprivation ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24492492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24492492 #FOAvip English Wikipedia <ref>{{Cite pmid|24492492}}</ref> NOX4 regulates autophagy during energy deprivation #MMPMID24492492 Sciarretta S; Volpe M; Sadoshima J Autophagy 2014[Apr]; 10 (4): 699-701 PMID24492492show ga NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress. NOX4 activity and protein levels are increased in the endoplasmic reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase of energy deprivation. NOX4-derived production of ROS in the ER is a critical event that activates autophagy through stimulation of the EIF2AK3/PERK-EIF2S1/eIF-2?-ATF4 pathway. NOX4-dependent autophagy is an important mechanism to preserve cellular energy and limit cell death in energy-deprived cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4 during cellular energy stress, our study dissects a novel signaling mechanism that regulates autophagy under this condition. äNOX4 regulates autophagy during energy deprivation (epmc).pdf DeepDyve Pubget Overpricing