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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Autophagy 2014 ; 10 (4): 691-3 Nephropedia Template TP
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Seeing is believing: Dynamic changes in renal epithelial autophagy during injury and repair #MMPMID24434795
Lin F; Wang ZV; Hill JA
Autophagy 2014[Apr]; 10 (4): 691-3 PMID24434795show ga
Ischemic injury to the kidneys is a prevalent clinical problem, contributing importantly to chronic kidney disease. Yet, underlying molecular mechanisms are elusive. To address the possible role of autophagy, we engineered a novel strain of mice harboring a ubiquitously expressed CAG-RFP-EGFP-LC3 transgene. Using this tool, we examined the post-ischemic kidney and detailed the dynamics of renal tubular epithelial autophagy. In addition, we defined the role of MTOR in the resolution of autophagy during epithelial survival and kidney repair.