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10.1111/cei.12327 http://scihub22266oqcxt.onion/10.1111/cei.12327 C4089169!4089169!24635044     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2014 ; 177 (1): 203-11 Nephropedia Template TP {{tp|p=24635044|t=2014. CD84 is markedly up-regulated in Kawasaki disease arteriopathy |pdf=|usr=}}{{24635044}} gab.com Text CD84 is markedly up-regulated in Kawasaki disease arteriopathy JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24635044 #FOAvip The major goals of Kawasaki disease (KD) therapy are to reduce inflammation and prevent thrombosis in the coronary arteries (CA), but some children do not respond to currently available non-specific therapies. New treatments have been difficult to develop because the molecular pathogenesis is unknown. In order to identify dysregulated gene expression in KD CA, we performed high-throughput RNA sequencing on KD and control CA, validated potentially dysregulated genes by real-time reverse transcription?polymerase chain reaction (RT?PCR) and localized protein expression by immunohistochemistry. Signalling lymphocyte activation molecule CD84 was up-regulated 16-fold (P < 0·01) in acute KD CA (within 2 months of onset) and 32-fold (P < 0·01) in chronic CA (5 months to years after onset). CD84 was localized to inflammatory cells in KD tissues. Genes associated with cellular proliferation, motility and survival were also up-regulated in KD CA, and immune activation molecules MX2 and SP140 were up-regulated in chronic KD. CD84, which facilitates immune responses and stabilizes platelet aggregates, is markedly up-regulated in KD CA in patients with acute and chronic arterial disease. We provide the first molecular evidence of dysregulated inflammatory responses persisting for months to years in CA significantly damaged by KD. Twit Text FOAVip CD84 is markedly up-regulated in Kawasaki disease arteriopathy ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24635044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24635044 #FOAvip English Wikipedia <ref>{{Cite pmid|24635044}}</ref> CD84 is markedly up-regulated in Kawasaki disease arteriopathy #MMPMID24635044 Reindel R; Bischof J; Kim KYA; Orenstein JM; Soares MB; Baker SC; Shulman ST; Perlman EJ; Lingen MW; Pink AJ; Trevenen C; Rowley AH Clin Exp Immunol 2014[Jul]; 177 (1): 203-11 PMID24635044show ga The major goals of Kawasaki disease (KD) therapy are to reduce inflammation and prevent thrombosis in the coronary arteries (CA), but some children do not respond to currently available non-specific therapies. New treatments have been difficult to develop because the molecular pathogenesis is unknown. In order to identify dysregulated gene expression in KD CA, we performed high-throughput RNA sequencing on KD and control CA, validated potentially dysregulated genes by real-time reverse transcription?polymerase chain reaction (RT?PCR) and localized protein expression by immunohistochemistry. Signalling lymphocyte activation molecule CD84 was up-regulated 16-fold (P < 0·01) in acute KD CA (within 2 months of onset) and 32-fold (P < 0·01) in chronic CA (5 months to years after onset). CD84 was localized to inflammatory cells in KD tissues. Genes associated with cellular proliferation, motility and survival were also up-regulated in KD CA, and immune activation molecules MX2 and SP140 were up-regulated in chronic KD. CD84, which facilitates immune responses and stabilizes platelet aggregates, is markedly up-regulated in KD CA in patients with acute and chronic arterial disease. We provide the first molecular evidence of dysregulated inflammatory responses persisting for months to years in CA significantly damaged by KD. äCD84 is markedly up-regulated in Kawasaki disease arteriopathy (epmc).pdf DeepDyve Pubget Overpricing