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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurotrauma
2014 ; 31
(13
): 1129-38
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gab.com Text
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English Wikipedia
Linking traumatic brain injury to chronic traumatic encephalopathy:
identification of potential mechanisms leading to neurofibrillary tangle
development
#MMPMID24499307
Lucke-Wold BP
; Turner RC
; Logsdon AF
; Bailes JE
; Huber JD
; Rosen CL
J Neurotrauma
2014[Jul]; 31
(13
): 1129-38
PMID24499307
show ga
Significant attention has recently been drawn to the potential link between head
trauma and the development of neurodegenerative disease, namely chronic traumatic
encephalopathy (CTE). The acute neurotrauma associated with sports-related
concussions in athletes and blast-induced traumatic brain injury in soldiers
elevates the risk for future development of chronic neurodegenerative diseases
such as CTE. CTE is a progressive disease distinguished by characteristic tau
neurofibrillary tangles (NFTs) and, occasionally, transactive response DNA
binding protein 43 (TDP43) oligomers, both of which have a predilection for
perivascular and subcortical areas near reactive astrocytes and microglia. The
disease is currently only diagnosed postmortem by neuropathological
identification of NFTs. A recent workshop sponsored by National Institute of
Neurological Disorders and Stroke emphasized the need for premortem diagnosis, to
better understand disease pathophysiology and to develop targeted treatments. In
order to accomplish this objective, it is necessary to discover the mechanistic
link between acute neurotrauma and the development of chronic neurodegenerative
and neuropsychiatric disorders such as CTE. In this review, we briefly summarize
what is currently known about CTE development and pathophysiology, and
subsequently discuss injury-induced pathways that warrant further investigation.
Understanding the mechanistic link between acute brain injury and chronic
neurodegeneration will facilitate the development of appropriate diagnostic and
therapeutic options for CTE and other related disorders.