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10.1038/mt.2014.62 http://scihub22266oqcxt.onion/10.1038/mt.2014.62 C4089009!4089009 !24736278     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24736278 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD |pdf=|usr=}}{{24736278 }} gab.com Text Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24736278 #FOAvip Stem cell therapy is a promising approach to regenerate healthy tissues starting from a limited amount of self-renewing cells. Immunological rejection of cell therapy products might represent a major limitation. In this study, we investigated the immunological functional profile of mesoangioblasts, vessel-associated myogenic stem cells, currently tested in a phase 1-2a trial, active in our Institute, for the treatment of Duchenne muscular dystrophy. We report that in resting conditions, human mesoangioblasts are poorly immunogenic, inefficient in promoting the expansion of alloreactive T cells and intrinsically resistant to T-cell killing. However, upon exposure to interferon-? or differentiation into myotubes, mesoangioblasts acquire the ability to promote the expansion of alloreactive T cells and acquire sensitivity to T-cell killing. Resistance of mesoangioblasts to T-cell killing is largely due to the expression of the intracellular serine protease inhibitor-9 and represents a relevant mechanism of stem cell immune evasion. Twit Text FOAVip Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24736278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24736278 #FOAvip English Wikipedia <ref>{{Cite pmid|24736278 }}</ref> Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD #MMPMID24736278 Noviello M ; Tedesco FS ; Bondanza A ; Tonlorenzi R ; Rosaria Carbone M ; Gerli MFM ; Marktel S ; Napolitano S ; Cicalese MP ; Ciceri F ; Peretti G ; Cossu G ; Bonini C Mol Ther 2014[Jul]; 22 (7 ): 1342-1352 PMID24736278 show ga Stem cell therapy is a promising approach to regenerate healthy tissues starting from a limited amount of self-renewing cells. Immunological rejection of cell therapy products might represent a major limitation. In this study, we investigated the immunological functional profile of mesoangioblasts, vessel-associated myogenic stem cells, currently tested in a phase 1-2a trial, active in our Institute, for the treatment of Duchenne muscular dystrophy. We report that in resting conditions, human mesoangioblasts are poorly immunogenic, inefficient in promoting the expansion of alloreactive T cells and intrinsically resistant to T-cell killing. However, upon exposure to interferon-? or differentiation into myotubes, mesoangioblasts acquire the ability to promote the expansion of alloreactive T cells and acquire sensitivity to T-cell killing. Resistance of mesoangioblasts to T-cell killing is largely due to the expression of the intracellular serine protease inhibitor-9 and represents a relevant mechanism of stem cell immune evasion. |Cell Differentiation [MESH] |Cell- and Tissue-Based Therapy/*methods [MESH] |Cells, Cultured [MESH] |Humans [MESH] |Interferon-gamma [MESH] |Muscular Dystrophy, Duchenne/*therapy [MESH]Inflammation converts human mesoangioblasts into targets of alloreacti(epmc).pdf DeepDyve Pubget Overpricing