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10.1089/jamp.2013.1042 http://scihub22266oqcxt.onion/10.1089/jamp.2013.1042 C4088352!4088352!23668548     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Aerosol+Med+Pulm+Drug+Deliv 2014 ; 27 (3): 178-84 Nephropedia Template TP {{tp|p=23668548|t=2014. Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients |pdf=|usr=}}{{23668548}} gab.com Text Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients JO: J Aerosol Med Pulm Drug Deliv http://www.kidney.de/pget.php?&tw=1&pmid=23668548 #FOAvip Background: Inhaled cyclosporine (CsA) is being investigated as a prophylaxis for lung transplant rejection. Lung deposition and systemic exposure of nebulized CsA in lung transplant patients was evaluated as part of the Phase 3 cyclosporine inhalation solution (CIS) trial (CYCLIST).Methods: Ten patients received 300?mg of CIS (62.5?mg/mL CsA in propylene glycol) admixed with 148?MBq of Tc-DTPA (technetium-99m bound to diethylenetriaminepentaacetic acid) administered using a Sidestream® disposable jet nebulizer. Deposition was assessed using a dual-headed gamma camera. Blood samples were collected over a 24-hr time period after aerosol dosing and analyzed for CsA levels. A pharmacokinetic analysis of the resulting blood concentration versus time profiles was performed.Results: The average total deposited dose was 53.7±12.7?mg. Average pulmonary dose was 31.8±16.3?mg, and stomach dose averaged 15.5±11.1?mg. Device performance was consistent, with breathing maneuvers influencing dose variation. Predose coaching with five of 10 patients reduced stomach deposition (22.6±11.2 vs. 8.3±5.2?mg; p=0.03). Blood concentrations declined quickly from a maximum of 372±140?ng/mL to 15.3±9.7?ng/mL at 24?hr post dose. Levels of AUC(0?24) [area under the concentration vs. time curve from 0 to 24?hr] averaged 1,493±746?ng hr/mL. On a three times per week dose regimen, this represents <5% of the weekly systemic exposure of twice per day oral administration.Conclusions: Substantial doses of CsA can be delivered to the lungs of lung transplant patients by inhaled aerosol. Systemic levels are small relative to typical oral CsA administration. Twit Text FOAVip Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients ????J Aerosol Med Pulm Drug Deliv http://www.kidney.de/pget.php?&tw=1&pmid=23668548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23668548 #FOAvip English Wikipedia <ref>{{Cite pmid|23668548}}</ref> Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients #MMPMID23668548 Corcoran T; Niven R; Verret W; Dilly S; Johnson B J Aerosol Med Pulm Drug Deliv 2014[Jun]; 27 (3): 178-84 PMID23668548show ga Background: Inhaled cyclosporine (CsA) is being investigated as a prophylaxis for lung transplant rejection. Lung deposition and systemic exposure of nebulized CsA in lung transplant patients was evaluated as part of the Phase 3 cyclosporine inhalation solution (CIS) trial (CYCLIST).Methods: Ten patients received 300?mg of CIS (62.5?mg/mL CsA in propylene glycol) admixed with 148?MBq of Tc-DTPA (technetium-99m bound to diethylenetriaminepentaacetic acid) administered using a Sidestream® disposable jet nebulizer. Deposition was assessed using a dual-headed gamma camera. Blood samples were collected over a 24-hr time period after aerosol dosing and analyzed for CsA levels. A pharmacokinetic analysis of the resulting blood concentration versus time profiles was performed.Results: The average total deposited dose was 53.7±12.7?mg. Average pulmonary dose was 31.8±16.3?mg, and stomach dose averaged 15.5±11.1?mg. Device performance was consistent, with breathing maneuvers influencing dose variation. Predose coaching with five of 10 patients reduced stomach deposition (22.6±11.2 vs. 8.3±5.2?mg; p=0.03). Blood concentrations declined quickly from a maximum of 372±140?ng/mL to 15.3±9.7?ng/mL at 24?hr post dose. Levels of AUC(0?24) [area under the concentration vs. time curve from 0 to 24?hr] averaged 1,493±746?ng hr/mL. On a three times per week dose regimen, this represents <5% of the weekly systemic exposure of twice per day oral administration.Conclusions: Substantial doses of CsA can be delivered to the lungs of lung transplant patients by inhaled aerosol. Systemic levels are small relative to typical oral CsA administration. äLung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung(epmc).pdf DeepDyve Pubget Overpricing