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10.1007/s10875-014-0040-5 http://scihub22266oqcxt.onion/10.1007/s10875-014-0040-5 C4083752!4083752!24789684     free     free     free       J+Clin+Immunol 2014 ; 34 (0 1): 56-60 Nephropedia Template TP {{tp|p=24789684|t=2014. Unexpected targets and triggers of autoimmunity |pdf=|usr=}}{{24789684}} gab.com Text Unexpected targets and triggers of autoimmunity JO: J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24789684 #FOAvip Recent findings indicate that the role of Th17 cells in the pathogenesis of tissue inflammation and autoimmunity has become rather complicated. While interleukin-17 (IL-17) producing CD4+ T cells are found frequently within the peripheral target tissue during the course of autoimmune disease, these cells may contribute to or protect from inflammation. Accumulating reports have revealed the existence of both pathogenic and non-pathogenic Th17 cells. These Th17 subsets produce the signature cytokines IL-17A and IL-17F yet have distinct and divergent roles in inducing autoimmune tissue inflammation. Comparative genomic sequence analyses between the pathogenic and non-pathogenic Th17 cells have exposed unexpected and extensive population heterogeneity within the Th17 subset. Here we review some of the unexpected factors that may drive pathogenic divergence. Understanding the functional consequences of Th17 cell diversity may allow for the selection of more precise targets for intervention in autoimmune and inflammatory diseases. Twit Text FOAVip Unexpected targets and triggers of autoimmunity ????J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24789684 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24789684 #FOAvip English Wikipedia <ref>{{Cite pmid|24789684}}</ref> Unexpected targets and triggers of autoimmunity #MMPMID24789684 Lee Y; Collins M; Kuchroo VK J Clin Immunol 2014[Jul]; 34 (0 1): 56-60 PMID24789684show ga Recent findings indicate that the role of Th17 cells in the pathogenesis of tissue inflammation and autoimmunity has become rather complicated. While interleukin-17 (IL-17) producing CD4+ T cells are found frequently within the peripheral target tissue during the course of autoimmune disease, these cells may contribute to or protect from inflammation. Accumulating reports have revealed the existence of both pathogenic and non-pathogenic Th17 cells. These Th17 subsets produce the signature cytokines IL-17A and IL-17F yet have distinct and divergent roles in inducing autoimmune tissue inflammation. Comparative genomic sequence analyses between the pathogenic and non-pathogenic Th17 cells have exposed unexpected and extensive population heterogeneity within the Th17 subset. Here we review some of the unexpected factors that may drive pathogenic divergence. Understanding the functional consequences of Th17 cell diversity may allow for the selection of more precise targets for intervention in autoimmune and inflammatory diseases. äUnexpected targets and triggers of autoimmunity (epmc).pdf DeepDyve Pubget Overpricing