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10.1161/CIRCRESAHA.114.302530 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.114.302530 C4083003!4083003!24650916     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Res 2014 ; 114 (9): 1422-34 Nephropedia Template TP {{tp|p=24650916|t=2014. Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair |pdf=|usr=}}{{24650916}} gab.com Text Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24650916 #FOAvip Rationale: Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment but appreciation of their contribution has suffered from incomplete characterization and lack of cell-specific markers. Objective: To generate an unbiased comparative gene expression profile of the cardiac fibroblast pool, identify and characterize the role of key genes in cardiac fibroblast function, and determine their contribution to myocardial development and regeneration. Methods and Results: High-throughput cell surface and intracellular profiling of cardiac and tail fibroblasts identified canonical MSC and a surprising number of cardiogenic genes, some expressed at higher levels than in whole heart. Whilst genetically marked fibroblasts contributed heterogeneously to interstitial but not cardiomyocyte compartments in infarcted hearts, fibroblast-restricted depletion of one highly expressed cardiogenic marker, Tbx20, caused marked myocardial dysmorphology and perturbations in scar formation upon myocardial infarction. Conclusions: The surprising transcriptional identity of cardiac fibroblasts, the adoption of cardiogenic gene programs and direct contribution to cardiac development and repair provokes alternative interpretations for studies on more specialized cardiac progenitors, offering a novel perspective for reinterpreting cardiac regenerative therapies. Twit Text FOAVip Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24650916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24650916 #FOAvip English Wikipedia <ref>{{Cite pmid|24650916}}</ref> Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair #MMPMID24650916 Furtado MB; Costa MW; Pranoto EA; Salimova E; Pinto A; Lam NT; Park A; Snider P; Chandran A; Harvey RP; Boyd R; Conway SJ; Pearson J; Kaye DM; Rosenthal NA Circ Res 2014[Apr]; 114 (9): 1422-34 PMID24650916show ga Rationale: Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment but appreciation of their contribution has suffered from incomplete characterization and lack of cell-specific markers. Objective: To generate an unbiased comparative gene expression profile of the cardiac fibroblast pool, identify and characterize the role of key genes in cardiac fibroblast function, and determine their contribution to myocardial development and regeneration. Methods and Results: High-throughput cell surface and intracellular profiling of cardiac and tail fibroblasts identified canonical MSC and a surprising number of cardiogenic genes, some expressed at higher levels than in whole heart. Whilst genetically marked fibroblasts contributed heterogeneously to interstitial but not cardiomyocyte compartments in infarcted hearts, fibroblast-restricted depletion of one highly expressed cardiogenic marker, Tbx20, caused marked myocardial dysmorphology and perturbations in scar formation upon myocardial infarction. Conclusions: The surprising transcriptional identity of cardiac fibroblasts, the adoption of cardiogenic gene programs and direct contribution to cardiac development and repair provokes alternative interpretations for studies on more specialized cardiac progenitors, offering a novel perspective for reinterpreting cardiac regenerative therapies. äCardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart(epmc).pdf DeepDyve Pubget Overpricing