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10.1016/j.cell.2014.05.035 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.05.035 C4082802!4082802!24995985     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 158 (1): 143-56 Nephropedia Template TP {{tp|p=24995985|t=2014. Cytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts complex |pdf=|usr=}}{{24995985}} gab.com Text Cytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts complex JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24995985 #FOAvip Mechanical forces have been proposed to modulate organ growth, but a molecular mechanism that links them to growth regulation in vivo has been lacking. We report that increasing tension within the cytoskeleton increases Drosophila wing growth, whereas decreasing cytoskeletal tension decreases wing growth. These changes in growth can be accounted for by changes in the activity of Yorkie, a transcription factor regulated by the Hippo pathway. The influence of myosin activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative regulator of Warts within the Hippo pathway. We further show that Jub associates with ?-catenin, and that its localization to adherens junctions and association with ?-catenin are promoted by cytoskeletal tension. Jub recruits Warts to junctions in a tension-dependent manner. Our observations delineate a mechanism that links cytoskeletal tension to regulation of Hippo pathway activity, providing a molecular understanding of how mechanical forces can modulate organ growth. Twit Text FOAVip Cytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts complex ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24995985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24995985 #FOAvip English Wikipedia <ref>{{Cite pmid|24995985}}</ref> Cytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts complex #MMPMID24995985 Rauskolb C; Sun S; Sun G; Pan Y; Irvine KD Cell 2014[Jul]; 158 (1): 143-56 PMID24995985show ga Mechanical forces have been proposed to modulate organ growth, but a molecular mechanism that links them to growth regulation in vivo has been lacking. We report that increasing tension within the cytoskeleton increases Drosophila wing growth, whereas decreasing cytoskeletal tension decreases wing growth. These changes in growth can be accounted for by changes in the activity of Yorkie, a transcription factor regulated by the Hippo pathway. The influence of myosin activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative regulator of Warts within the Hippo pathway. We further show that Jub associates with ?-catenin, and that its localization to adherens junctions and association with ?-catenin are promoted by cytoskeletal tension. Jub recruits Warts to junctions in a tension-dependent manner. Our observations delineate a mechanism that links cytoskeletal tension to regulation of Hippo pathway activity, providing a molecular understanding of how mechanical forces can modulate organ growth. äCytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts c(epmc).pdf DeepDyve Pubget Overpricing