Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24664801
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Age+(Dordr)
2014 ; 36
(3
): 9641
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Glomerular filtration rate in the elderly and in the oldest old: correlation with
frailty and mortality
#MMPMID24664801
Montesanto A
; De Rango F
; Berardelli M
; Mari V
; Lattanzio F
; Passarino G
; Corsonello A
Age (Dordr)
2014[Jun]; 36
(3
): 9641
PMID24664801
show ga
The equations for estimating kidney function have become very popular in the last
decade. However, the clinical and prognostic meaning of these measures may be
very different in older populations. Two cohorts of people aged 65-89 years
(older sample) and 90 or more (oldest old sample) were used to investigate the
prognostic significance of estimated glomerular filtration rate (eGFR).
Additionally, we also investigated whether combining frailty and eGFR may improve
the accuracy of frailty in predicting mortality. We found that lower eGFR values
were significantly more frequent among frail subjects in both groups. eGFR?30
was associated with increased risk for all-cause mortality either in subjects
aged 65-89 years (HR?=?3.71, 95% CI?=?1.23-11.2) or in those aged 90 or more
(HR?=?1.53, 95% CI?=?1.05-2.23). In the latter group, a not significant trend for
increasing mortality was also observed among people with eGFR?>?60 (HR?=?1.28,
95% CI?=?0.72-2.26). In addition, the oldest old subjects with eGFR?>?60 and
eGFR?30 had the lowest hand-grip strength and ADL values. Combining eGFR and
frailty status significantly improved the accuracy of frailty in predicting
mortality only in the older sample. In conclusion, a U-shaped relationship exists
between eGFR and mortality in the oldest old, but not in older individuals. Our
findings suggest that eGFR needs to be adjusted for muscle mass/physical
performance when estimating kidney function in people aged 90 or more.
Nevertheless, in subjects aged 65-89 years, eGFR may improve the accuracy of
frailty status in predicting prognosis, thus suggesting that eGFR may represent
an additional dimension of frailty syndrome.
|*Aging
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Female
[MESH]
|Frail Elderly/*statistics & numerical data
[MESH]