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10.1007/s11357-014-9623-6 http://scihub22266oqcxt.onion/10.1007/s11357-014-9623-6 C4082581!4082581!24550076     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Age+(Dordr) 2014 ; 36 (3): ä Nephropedia Template TP {{tp|p=24550076|t=2014. Oxidative exposure impairs TGF-? pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts |pdf=|usr=}}{{24550076}} gab.com Text Oxidative exposure impairs TGF- pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts JO: Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases. Here, we report that brief, low-level oxidative exposure leads to long-term elevation of cellular reactive oxygen species (ROS) levels and oxidative damage in human skin fibroblasts. Elevated ROS impairs the transforming growth factor-? (TGF-?) pathway, through reduction of type II TGF-? receptor (T?RII) and SMAD3 protein levels. This impairment results in reduced expression of connective tissue growth factor (CTGF/CCN2) and type I collagen, which are regulated by TGF-?. Restoration of T?RII and SMAD3 together, but not separately, reinstates TGF-? signaling and increases CTGF/CCN2 and type I collagen levels. Treatment with the anti-oxidant N-acetylcysteine reduces ROS elevation and normalizes TGF-? signaling and target gene expression. These data reveal a novel linkage between limited oxidant exposure and altered cellular redox homeostasis that results in impairment of TGF-? signaling. This linkage provides new insights regarding the mechanism by which aberrant redox homeostasis is coupled to decline of collagen production, a hallmark of human skin aging.Electronic supplementary material: The online version of this article (doi:10.1007/s11357-014-9623-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Oxidative exposure impairs TGF- pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts ????Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip English Wikipedia <ref>{{Cite pmid|24550076}}</ref> Oxidative exposure impairs TGF-? pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts #MMPMID24550076 He T; Quan T; Shao Y; Voorhees JJ; Fisher GJ Age (Dordr) 2014[Jun]; 36 (3): ä PMID24550076show ga Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases. Here, we report that brief, low-level oxidative exposure leads to long-term elevation of cellular reactive oxygen species (ROS) levels and oxidative damage in human skin fibroblasts. Elevated ROS impairs the transforming growth factor-? (TGF-?) pathway, through reduction of type II TGF-? receptor (T?RII) and SMAD3 protein levels. This impairment results in reduced expression of connective tissue growth factor (CTGF/CCN2) and type I collagen, which are regulated by TGF-?. Restoration of T?RII and SMAD3 together, but not separately, reinstates TGF-? signaling and increases CTGF/CCN2 and type I collagen levels. Treatment with the anti-oxidant N-acetylcysteine reduces ROS elevation and normalizes TGF-? signaling and target gene expression. These data reveal a novel linkage between limited oxidant exposure and altered cellular redox homeostasis that results in impairment of TGF-? signaling. This linkage provides new insights regarding the mechanism by which aberrant redox homeostasis is coupled to decline of collagen production, a hallmark of human skin aging.Electronic supplementary material: The online version of this article (doi:10.1007/s11357-014-9623-6) contains supplementary material, which is available to authorized users. äOxidative exposure impairs TGF-? pathway via reduction of type II rece(epmc).pdf DeepDyve Pubget Overpricing