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10.1007/s11357-014-9623-6 http://scihub22266oqcxt.onion/10.1007/s11357-014-9623-6 C4082581!4082581 !24550076     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24550076 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Age+(Dordr) 2014 ; 36 (3 ): 9623 Nephropedia Template TP {{tp|p=24550076 |t=2014. Oxidative exposure impairs TGF-? pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts |pdf=|usr=}}{{24550076 }} gab.com Text Oxidative exposure impairs TGF- pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts JO: Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases. Here, we report that brief, low-level oxidative exposure leads to long-term elevation of cellular reactive oxygen species (ROS) levels and oxidative damage in human skin fibroblasts. Elevated ROS impairs the transforming growth factor-? (TGF-?) pathway, through reduction of type II TGF-? receptor (T?RII) and SMAD3 protein levels. This impairment results in reduced expression of connective tissue growth factor (CTGF/CCN2) and type I collagen, which are regulated by TGF-?. Restoration of T?RII and SMAD3 together, but not separately, reinstates TGF-? signaling and increases CTGF/CCN2 and type I collagen levels. Treatment with the anti-oxidant N-acetylcysteine reduces ROS elevation and normalizes TGF-? signaling and target gene expression. These data reveal a novel linkage between limited oxidant exposure and altered cellular redox homeostasis that results in impairment of TGF-? signaling. This linkage provides new insights regarding the mechanism by which aberrant redox homeostasis is coupled to decline of collagen production, a hallmark of human skin aging. Twit Text FOAVip Oxidative exposure impairs TGF- pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts ????Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24550076 #FOAvip English Wikipedia <ref>{{Cite pmid|24550076 }}</ref> Oxidative exposure impairs TGF-? pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts #MMPMID24550076 He T ; Quan T ; Shao Y ; Voorhees JJ ; Fisher GJ Age (Dordr) 2014[Jun]; 36 (3 ): 9623 PMID24550076 show ga Exposure to oxidants results in cellular alterations that are implicated in aging and age-associated diseases. Here, we report that brief, low-level oxidative exposure leads to long-term elevation of cellular reactive oxygen species (ROS) levels and oxidative damage in human skin fibroblasts. Elevated ROS impairs the transforming growth factor-? (TGF-?) pathway, through reduction of type II TGF-? receptor (T?RII) and SMAD3 protein levels. This impairment results in reduced expression of connective tissue growth factor (CTGF/CCN2) and type I collagen, which are regulated by TGF-?. Restoration of T?RII and SMAD3 together, but not separately, reinstates TGF-? signaling and increases CTGF/CCN2 and type I collagen levels. Treatment with the anti-oxidant N-acetylcysteine reduces ROS elevation and normalizes TGF-? signaling and target gene expression. These data reveal a novel linkage between limited oxidant exposure and altered cellular redox homeostasis that results in impairment of TGF-? signaling. This linkage provides new insights regarding the mechanism by which aberrant redox homeostasis is coupled to decline of collagen production, a hallmark of human skin aging. |*Gene Expression Regulation, Developmental [MESH] |Acetylcysteine/pharmacology [MESH] |Collagen Type I/metabolism [MESH] |Fibroblasts/cytology/drug effects/*metabolism [MESH] |Free Radical Scavengers/pharmacology [MESH] |Humans [MESH] |Protein Serine-Threonine Kinases/biosynthesis/drug effects/*genetics [MESH] |RNA, Messenger/*genetics [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/biosynthesis/drug effects/*genetics [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction [MESH] |Skin Aging/drug effects/*genetics [MESH] |Skin/cytology/drug effects/*metabolism [MESH]Oxidative exposure impairs TGF-? pathway via reduction of type II rece(epmc).pdf DeepDyve Pubget Overpricing