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2014 ; 23
(2
): 93-100
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A Randomized Comparison between Everolimus-Eluting Stent and Cobalt Chromium
Stent in Patients with Acute ST-Elevation Myocardial Infarction Undergoing
Primary Percutaneous Coronary Intervention Using Routine Intravenous
Eptifibatide: The X-MAN (Xience vs Multi-Link Stent in Acute Myocardial
Infarction) Trial, A Pilot Study
#MMPMID25075161
Dharma S
; Wardeh AJ
; Soerianata S
; Firdaus I
; Jukema JW
Int J Angiol
2014[Jun]; 23
(2
): 93-100
PMID25075161
show ga
The objective of this study is to determine the efficacy and safety of an
everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared
with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in
patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary
percutaneous coronary intervention (PCI) with routine administration of
eptifibatide infusion. This is a prospective, single center, randomized trial
comparing EES (n?=?75) and CoCr stent (n?=?75) implantation in patients with
acute STEMI undergoing primary PCI. Intravenous eptifibatide administration was
mandatory by protocol in this pilot study. The primary efficacy endpoint was
major adverse cardiac events (MACE) at 30 days, defined as the composite of
death, reinfarction, and target vessel revascularization. Secondary safety
endpoints were stent thrombosis at 30 days and in-hospital bleeding event. Acute
reperfusion parameters were also assessed. One-month MACE rate did not differ
between EES and CoCr group (1.3 vs. 1.3%, p?=?1.0). No stent thrombosis cases
were observed in the EES group. The groups did not differ with respect to
in-hospital bleeding events (5 vs. 9%, p?=?0.37), achievement of final
thrombolysis in myocardial infarction flow 2 or 3 (p?=?0.21), achievement of
myocardial blush grade 2 or 3 (p?=?0.45), creatine kinase-MB level at 8 to 12
hours after stenting (p?=?0.29), and left ventricular ejection fraction
(p?=?0.21). This pilot study demonstrates that after one-month follow-up, the use
of EES is as safe and effective as the use of CoCr stents in patients with acute
STEMI undergoing primary PCI with routine administration of intravenous
eptifibatide.