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10.1074/jbc.M114.563650

http://scihub22266oqcxt.onion/10.1074/jbc.M114.563650
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C4081918!4081918!24855646
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suck abstract from ncbi


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pmid24855646      J+Biol+Chem 2014 ; 289 (27): 18736-51
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  • The Epigenetic Drug 5-Azacytidine Interferes with Cholesterol and Lipid Metabolism* #MMPMID24855646
  • Poirier S; Samami S; Mamarbachi M; Demers A; Chang TY; Vance DE; Hatch GM; Mayer G
  • J Biol Chem 2014[Jul]; 289 (27): 18736-51 PMID24855646show ga
  • Background: The anticancer drug 5-azacytidine acts through an incompletely understood mechanism.Results: 5-Azacytidine reprograms the glycerolipid biosynthesis pathway and prevents activation of master transcription factors that regulate lipid homeostasis.Conclusion: 5-Azacytidine deeply modifies how cells manage cholesterol and lipid synthesis.Significance: The findings unravel important insights into the mechanism of 5-azacytidine and highlight new potential cancer therapeutics.
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