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10.1016/j.stem.2014.01.014 http://scihub22266oqcxt.onion/10.1016/j.stem.2014.01.014 C4080817!4080817!24561083     free     free     free       Cell+Stem+Cell 2014 ; 14 (4): 500-11 Nephropedia Template TP {{tp|p=24561083|t=2014. Axonal Control of the Adult Neural Stem Cell Niche |pdf=|usr=}}{{24561083}} gab.com Text Axonal Control of the Adult Neural Stem Cell Niche JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24561083 #FOAvip The ventricular-subventricular zone (V-SVZ) is an extensive germinal niche containing neural stem cells (NSC) in the walls of the lateral ventricles of the adult brain. How the adult brain?s neural activity influences the behavior of adult NSCs remains largely unknown. We show that serotonergic (5HT) axons originating from a small group of neurons in the raphe form an extensive plexus on most of the ventricular walls. Electron microscopy revealed intimate contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a transsynaptic viral tracer injected into the raphe. B1 cells express the 5HT receptors 2C and 5A. Electrophysiology showed that activation of these receptors in B1 cells induced small inward currents. Intraventricular infusion of 5HT2C agonist or antagonist increased or decreased V-SVZ proliferation, respectively. These results indicate that supraependymal 5HT axons directly interact with NSCs to regulate neurogenesis via 5HT2C. Twit Text FOAVip Axonal Control of the Adult Neural Stem Cell Niche ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24561083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24561083 #FOAvip English Wikipedia <ref>{{Cite pmid|24561083}}</ref> Axonal Control of the Adult Neural Stem Cell Niche #MMPMID24561083 Tong CK; Chen J; Cebrián-Silla A; Mirzadeh Z; Obernier K; Guinto CD; Tecott LH; García-Verdugo JM; Kriegstein A; Alvarez-Buylla A Cell Stem Cell 2014[Apr]; 14 (4): 500-11 PMID24561083show ga The ventricular-subventricular zone (V-SVZ) is an extensive germinal niche containing neural stem cells (NSC) in the walls of the lateral ventricles of the adult brain. How the adult brain?s neural activity influences the behavior of adult NSCs remains largely unknown. We show that serotonergic (5HT) axons originating from a small group of neurons in the raphe form an extensive plexus on most of the ventricular walls. Electron microscopy revealed intimate contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a transsynaptic viral tracer injected into the raphe. B1 cells express the 5HT receptors 2C and 5A. Electrophysiology showed that activation of these receptors in B1 cells induced small inward currents. Intraventricular infusion of 5HT2C agonist or antagonist increased or decreased V-SVZ proliferation, respectively. These results indicate that supraependymal 5HT axons directly interact with NSCs to regulate neurogenesis via 5HT2C. äAxonal Control of the Adult Neural Stem Cell Niche (epmc).pdf DeepDyve Pubget Overpricing