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10.1016/j.fct.2014.03.015 http://scihub22266oqcxt.onion/10.1016/j.fct.2014.03.015 C4080314!4080314!24657363     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Food+Chem+Toxicol 2014 ; 68 (ä): 196-203 Nephropedia Template TP {{tp|p=24657363|t=2014. Immunomodulatory activity of orphan drug ElmironŽ in female B6C3F1/N mice |pdf=|usr=}}{{24657363}} gab.com Text Immunomodulatory activity of orphan drug ElmironŽ in female B6C3F1/N mice JO: Food Chem Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24657363 #FOAvip Interstitial cystitis (IC) is a chronic disorder characterized by bladder discomfort and urinary urgency in the absence of identifiable infection. Despite the expanding use in treatment of IC and other chronic conditions, the effects of ElmironŽ treatment on immune system remain unknown. Therefore, female B6C3F1/N mice were orally administered ElmironŽ daily for 28-days at doses of 63, 125, 250, 500 or 1000 mg/kg to evaluate its immunomodulatory effects. Mice treated with ElmironŽ had a significant increase in absolute numbers of splenic macrophages (63, 500 and 1000 mg/kg) and natural killer (NK) cells (250 and 1000 mg/kg). ElmironŽ treatment did not affect the humoral immune response or T cell proliferative response. However, innate immune responses such as phagocytosis by liver macrophages (1000 mg/kg) and NK cell activity were enhanced (500 and 1000 mg/kg). Further analysis using a disease resistance model showed that ElmironŽ -treated mice demonstrated significantly increased anti-tumor activity against B16F10 melanoma cells at the 500 and 1000 mg/kg doses. Collectively, we conclude that ElmironŽ administration stimulates the immune system, increasing numbers of specific cell populations and enhancing macrophage phagocytosis and NK cell activity in female B6C3F1/N mice. This augmentation may have largely contributed to the reduced number of B16F10 melanoma tumors. Twit Text FOAVip Immunomodulatory activity of orphan drug ElmironŽ in female B6C3F1/N mice ????Food Chem Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24657363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24657363 #FOAvip English Wikipedia <ref>{{Cite pmid|24657363}}</ref> Immunomodulatory activity of orphan drug ElmironŽ in female B6C3F1/N mice #MMPMID24657363 Thakur SA; Nyska A; White KL; Smith MJ; Auttachoat W; Germolec DR Food Chem Toxicol 2014[Jun]; 68 (ä): 196-203 PMID24657363show ga Interstitial cystitis (IC) is a chronic disorder characterized by bladder discomfort and urinary urgency in the absence of identifiable infection. Despite the expanding use in treatment of IC and other chronic conditions, the effects of ElmironŽ treatment on immune system remain unknown. Therefore, female B6C3F1/N mice were orally administered ElmironŽ daily for 28-days at doses of 63, 125, 250, 500 or 1000 mg/kg to evaluate its immunomodulatory effects. Mice treated with ElmironŽ had a significant increase in absolute numbers of splenic macrophages (63, 500 and 1000 mg/kg) and natural killer (NK) cells (250 and 1000 mg/kg). ElmironŽ treatment did not affect the humoral immune response or T cell proliferative response. However, innate immune responses such as phagocytosis by liver macrophages (1000 mg/kg) and NK cell activity were enhanced (500 and 1000 mg/kg). Further analysis using a disease resistance model showed that ElmironŽ -treated mice demonstrated significantly increased anti-tumor activity against B16F10 melanoma cells at the 500 and 1000 mg/kg doses. Collectively, we conclude that ElmironŽ administration stimulates the immune system, increasing numbers of specific cell populations and enhancing macrophage phagocytosis and NK cell activity in female B6C3F1/N mice. This augmentation may have largely contributed to the reduced number of B16F10 melanoma tumors. äImmunomodulatory activity of orphan drug ElmironŽ in female B6C3F1/N m(epmc).pdf DeepDyve Pubget Overpricing