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10.1152/ajpcell.00084.2014 http://scihub22266oqcxt.onion/10.1152/ajpcell.00084.2014 C4080181!4080181!24788248     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Cell+Physiol 2014 ; 307 (1): C25-38 Nephropedia Template TP {{tp|p=24788248|t=2014. Type-2 pericytes participate in normal and tumoral angiogenesis |pdf=|usr=}}{{24788248}} gab.com Text Type-2 pericytes participate in normal and tumoral angiogenesis JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24788248 #FOAvip Tissue growth and function depend on vascularization, and vascular insufficiency or excess exacerbates many human diseases. Identification of the biological processes involved in angiogenesis will dictate strategies to modulate reduced or excessive vessel formation. We examine the essential role of pericytes. Their heterogeneous morphology, distribution, origins, and physiology have been described. Using double-transgenic Nestin-GFP/NG2-DsRed mice, we identified two pericyte subsets. We found that Nestin-GFP?/NG2-DsRed+ (type-1) and Nestin-GFP+/NG2-DsRed+ (type-2) pericytes attach to the walls of small and large blood vessels in vivo; in vitro, type-2, but not type-1, pericytes spark endothelial cells to form new vessels. Matrigel assay showed that only type-2 pericytes participate in normal angiogenesis. Moreover, when cancer cells were transplanted into Nestin-GFP/NG2-DsRed mice, type-1 pericytes did not penetrate the tumor, while type-2 pericytes were recruited during its angiogenesis. As inhibition of angiogenesis is a promising strategy in cancer therapy, type-2 pericytes may provide a cellular target susceptible to signaling and pharmacological manipulation in treating malignancy. This work also reports the potential of type-2 pericytes to improve blood perfusion in ischemic hindlimbs, indicating their potential for treating ischemic illnesses. Twit Text FOAVip Type-2 pericytes participate in normal and tumoral angiogenesis ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24788248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24788248 #FOAvip English Wikipedia <ref>{{Cite pmid|24788248}}</ref> Type-2 pericytes participate in normal and tumoral angiogenesis #MMPMID24788248 Birbrair A; Zhang T; Wang ZM; Messi ML; Olson JD; Mintz A; Delbono O Am J Physiol Cell Physiol 2014[Jul]; 307 (1): C25-38 PMID24788248show ga Tissue growth and function depend on vascularization, and vascular insufficiency or excess exacerbates many human diseases. Identification of the biological processes involved in angiogenesis will dictate strategies to modulate reduced or excessive vessel formation. We examine the essential role of pericytes. Their heterogeneous morphology, distribution, origins, and physiology have been described. Using double-transgenic Nestin-GFP/NG2-DsRed mice, we identified two pericyte subsets. We found that Nestin-GFP?/NG2-DsRed+ (type-1) and Nestin-GFP+/NG2-DsRed+ (type-2) pericytes attach to the walls of small and large blood vessels in vivo; in vitro, type-2, but not type-1, pericytes spark endothelial cells to form new vessels. Matrigel assay showed that only type-2 pericytes participate in normal angiogenesis. Moreover, when cancer cells were transplanted into Nestin-GFP/NG2-DsRed mice, type-1 pericytes did not penetrate the tumor, while type-2 pericytes were recruited during its angiogenesis. As inhibition of angiogenesis is a promising strategy in cancer therapy, type-2 pericytes may provide a cellular target susceptible to signaling and pharmacological manipulation in treating malignancy. This work also reports the potential of type-2 pericytes to improve blood perfusion in ischemic hindlimbs, indicating their potential for treating ischemic illnesses. äType-2 pericytes participate in normal and tumoral angiogenesis (epmc).pdf DeepDyve Pubget Overpricing