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10.1152/ajprenal.00615.2013 http://scihub22266oqcxt.onion/10.1152/ajprenal.00615.2013 C4080160!4080160!24785188     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2014 ; 307 (1): F58-63 Nephropedia Template TP {{tp|p=24785188|t=2014. Sodium and potassium regulate endothelial phospholipase C-? and Bmx |pdf=|usr=}}{{24785188}} gab.com Text Sodium and potassium regulate endothelial phospholipase C- and Bmx JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24785188 #FOAvip The amount of Na+ and K+ in the diet promotes significant changes in endothelial cell function. In the present study, a series of in vitro and in vivo experiments determined the role of Na+ and K+ in the regulation of two pleckstrin homology domain-containing intracellular signaling molecules, phospholipase C (PLC)-?1 and epithelial and endothelial tyrosine kinase/bone marrow tyrosine kinase on chromosome X (Bmx), and agonist-generated Ca2+ signaling in the endothelium. Extracellular K+ concentration regulated the levels of activated PLC-?1, Bmx, and carbachol-stimulated intracellular Ca2+ mobilization in human endothelial cells. Additional experiments confirmed that high-conductance Ca2+-activated K+ channels and phosphatidylinositol 3-kinase mediated these effects. The content of Na+ and K+ in the diet also regulated Bmx levels in endothelial cells and activated PLC-?1 levels in rats in vivo. The effects of dietary K+ on Bmx were more pronounced in rats fed a high-salt diet compared with rats fed a low-salt diet. These experiments elucidated an endothelial cell signaling mechanism regulated by electrolytes, further demonstrating an integral relationship between endothelial cell function and dietary Na+ and K+ content. Twit Text FOAVip Sodium and potassium regulate endothelial phospholipase C- and Bmx ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24785188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24785188 #FOAvip English Wikipedia <ref>{{Cite pmid|24785188}}</ref> Sodium and potassium regulate endothelial phospholipase C-? and Bmx #MMPMID24785188 Ying WZ; Aaron KJ; Sanders PW Am J Physiol Renal Physiol 2014[Jul]; 307 (1): F58-63 PMID24785188show ga The amount of Na+ and K+ in the diet promotes significant changes in endothelial cell function. In the present study, a series of in vitro and in vivo experiments determined the role of Na+ and K+ in the regulation of two pleckstrin homology domain-containing intracellular signaling molecules, phospholipase C (PLC)-?1 and epithelial and endothelial tyrosine kinase/bone marrow tyrosine kinase on chromosome X (Bmx), and agonist-generated Ca2+ signaling in the endothelium. Extracellular K+ concentration regulated the levels of activated PLC-?1, Bmx, and carbachol-stimulated intracellular Ca2+ mobilization in human endothelial cells. Additional experiments confirmed that high-conductance Ca2+-activated K+ channels and phosphatidylinositol 3-kinase mediated these effects. The content of Na+ and K+ in the diet also regulated Bmx levels in endothelial cells and activated PLC-?1 levels in rats in vivo. The effects of dietary K+ on Bmx were more pronounced in rats fed a high-salt diet compared with rats fed a low-salt diet. These experiments elucidated an endothelial cell signaling mechanism regulated by electrolytes, further demonstrating an integral relationship between endothelial cell function and dietary Na+ and K+ content. äSodium and potassium regulate endothelial phospholipase C-? and Bmx (epmc).pdf DeepDyve Pubget Overpricing