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2014 ; 31
(7
): 51
Nephropedia Template TP
gab.com Text
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English Wikipedia
The association between single-nucleotide polymorphisms of TRPM7 gene and breast
cancer in Han Population of Northeast China
#MMPMID24952306
Shen B
; Sun L
; Zheng H
; Yang D
; Zhang J
; Zhang Q
Med Oncol
2014[Jul]; 31
(7
): 51
PMID24952306
show ga
Breast cancer is one of the most common cancer and remains the leading cause of
cancer-related deaths in women. There is increasing evidence suggesting that
TRPM7 plays a pivotal role in breast cancer progression and metastasis. In this
study, a case-control study was carried out to investigate the effects of SNPs in
TRPM7 genes in the development of breast cancer in Han Population of Northeast
China. A total of six SNPs (rs8042919, rs4775899, rs11635825, rs7173321,
rs616256, and rs11070795) were chosen and genotyped. Genotypes were analyzed
using a single-base primer extension assay. Chi-square (? (2)) test was used to
analyze statistical difference between control and patient groups in genotype and
allele frequencies. The genotype-specific risks and allele frequencies of
haplotypes in breast cancer patients and controls were estimated by OR and 95 %
confidence intervals. The G allele of rs8042919 was associated with a reduced
disease risk. The G allele of rs7173321 and particularly its homozygous GG
genotype are associated with an increased breast cancer risk. Two of the TRPM7
SNPs (rs8042919 and rs7173321) are associated with breast cancer patients in Han
Population of Northeast China.