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10.1158/0008-5472.CAN-13-2149 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-13-2149 C4079748!4079748!24786788     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (13): 3591-602 Nephropedia Template TP {{tp|p=24786788|t=2014. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis |pdf=|usr=}}{{24786788}} gab.com Text Oncogenic protein MTBP interacts with MYC to promote tumorigenesis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24786788 #FOAvip Despite its involvement in most human cancers, MYC continues to pose a challenge as a readily tractable therapeutic target. Here we identify the MYC transcriptional cofactors TIP48 and TIP49 and MYC as novel binding partners of MTBP, a functionally undefined protein that we show is oncogenic and overexpressed in many human cancers. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation and tumor development. In breast cancer specimens, we determined overexpression of both MYC and MTBP was associated with a reduction in 10-year patient survival compared to MYC overexpression alone. MTBP was also frequently co-amplified with MYC in many human cancers. Mechanistic investigations implicated associations with TIP48/TIP49 as well as MYC in MTBP function in cellular transformation and the growth of human breast cancer cells. Taken together, our findings show MTBP functions with MYC to promote malignancy, identifying this protein as a novel general therapeutic target in human cancer. Twit Text FOAVip Oncogenic protein MTBP interacts with MYC to promote tumorigenesis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24786788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24786788 #FOAvip English Wikipedia <ref>{{Cite pmid|24786788}}</ref> Oncogenic protein MTBP interacts with MYC to promote tumorigenesis #MMPMID24786788 Grieb BC; Gramling MW; Arrate MP; Chen X; Beauparlant SL; Haines DS; Xiao H; Eischen CM Cancer Res 2014[Jul]; 74 (13): 3591-602 PMID24786788show ga Despite its involvement in most human cancers, MYC continues to pose a challenge as a readily tractable therapeutic target. Here we identify the MYC transcriptional cofactors TIP48 and TIP49 and MYC as novel binding partners of MTBP, a functionally undefined protein that we show is oncogenic and overexpressed in many human cancers. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation and tumor development. In breast cancer specimens, we determined overexpression of both MYC and MTBP was associated with a reduction in 10-year patient survival compared to MYC overexpression alone. MTBP was also frequently co-amplified with MYC in many human cancers. Mechanistic investigations implicated associations with TIP48/TIP49 as well as MYC in MTBP function in cellular transformation and the growth of human breast cancer cells. Taken together, our findings show MTBP functions with MYC to promote malignancy, identifying this protein as a novel general therapeutic target in human cancer. äOncogenic protein MTBP interacts with MYC to promote tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing