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10.1158/0008-5472.CAN-13-3147 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-13-3147 C4079738!4079738!24786786     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (13): 3617-29 Nephropedia Template TP {{tp|p=24786786|t=2014. Loss of the Polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors |pdf=|usr=}}{{24786786}} gab.com Text Loss of the Polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24786786 #FOAvip In colon tumors, the transcription of many genes becomes deregulated by poorly defined epigenetic mechanisms that have been studied mainly in established cell lines. In this study, we used frozen human colon tissues to analyze patterns of histone modification and DNA cytosine methylation in cancer and matched normal mucosa specimens. DNA methylation is strongly targeted to bivalent H3K4me3- and H3K27me3-associated promoters, which lose both histone marks and acquire DNA methylation. However, we found that loss of the Polycomb mark H3K27me3 from bivalent promoters was accompanied often by activation of genes associated with cancer progression, including numerous stem cell regulators, oncogenes and proliferation-associated genes. Indeed, we found many of these same genes were also activated in ulcerative colitis patients where chronic inflammation predisposes them to colon cancer. Based on our findings, we propose that a loss of Polycomb repression at bivalent genes combined with an ensuing selection for tumor-driving events plays a major role in cancer progression. Twit Text FOAVip Loss of the Polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24786786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24786786 #FOAvip English Wikipedia <ref>{{Cite pmid|24786786}}</ref> Loss of the Polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors #MMPMID24786786 Hahn MA; Li AX; Wu X; Yang R; Drew DA; Rosenberg DW; Pfeifer GP Cancer Res 2014[Jul]; 74 (13): 3617-29 PMID24786786show ga In colon tumors, the transcription of many genes becomes deregulated by poorly defined epigenetic mechanisms that have been studied mainly in established cell lines. In this study, we used frozen human colon tissues to analyze patterns of histone modification and DNA cytosine methylation in cancer and matched normal mucosa specimens. DNA methylation is strongly targeted to bivalent H3K4me3- and H3K27me3-associated promoters, which lose both histone marks and acquire DNA methylation. However, we found that loss of the Polycomb mark H3K27me3 from bivalent promoters was accompanied often by activation of genes associated with cancer progression, including numerous stem cell regulators, oncogenes and proliferation-associated genes. Indeed, we found many of these same genes were also activated in ulcerative colitis patients where chronic inflammation predisposes them to colon cancer. Based on our findings, we propose that a loss of Polycomb repression at bivalent genes combined with an ensuing selection for tumor-driving events plays a major role in cancer progression. äLoss of the Polycomb mark from bivalent promoters leads to activation (epmc).pdf DeepDyve Pubget Overpricing