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2014 ; 23
(5
): 863-871
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Does d-Cycloserine Augmentation of CBT Improve Therapeutic Homework Compliance
for Pediatric Obsessive-Compulsive Disorder?
#MMPMID24999301
Park JM
; Small BJ
; Geller DA
; Murphy TK
; Lewin AB
; Storch EA
J Child Fam Stud
2014[Jul]; 23
(5
): 863-871
PMID24999301
show ga
Clinical studies in adults and children with obsessive-compulsive disorder (OCD)
have shown that d-cycloserine (DCS) can improve treatment response by enhancing
fear extinction learning during exposure-based psychotherapy. Some have
hypothesized that improved treatment response is a function of increased
compliance and engagement in therapeutic homework tasks, a core component of
behavioral treatment. The present study examined the relationship between DCS
augmented cognitive-behavioral therapy (CBT) and homework compliance in a
double-blind, placebo controlled trial with 30 youth with OCD. All children
received 10 CBT sessions, the last seven of which included exposure and response
prevention paired with DCS or placebo dosed 1 h before the session started.
Results suggested that DCS augmented CBT did not predict improved homework
compliance over the course of treatment, relative to the placebo augmented CBT
group. However, when groups were collapsed, homework compliance was directly
associated with treatment outcome. These findings suggest that while DCS may not
increase homework compliance over time, more generally, homework compliance is an
integral part of pediatric OCD treatment outcome.