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10.1161/CIRCRESAHA.114.302699

http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.114.302699
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C4078767!4078767!24902971
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suck abstract from ncbi


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pmid24902971      Circ+Res 2014 ; 114 (12): 1867-79
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  • Inflammation and its resolution as determinants of acute coronary syndromes #MMPMID24902971
  • Libby P; Tabas I; Fredman G; Fisher E
  • Circ Res 2014[Jun]; 114 (12): 1867-79 PMID24902971show ga
  • Inflammation contributes to many of the characteristics of plaques implicated in the pathogenesis of acute coronary syndromes (ACS). Moreover, inflammatory pathways not only regulate properties of plaques that precipitate ACS but also modulate the clinical consequences of the thrombotic complications of atherosclerosis. This synthesis will provide an update on the fundamental mechanisms of inflammatory responses that govern ACS, and also highlight the ongoing balance between pro-inflammatory mechanisms and endogenous pathways that can promote the resolution of inflammation. An appreciation of the countervailing mechanisms that modulate inflammation in relation to ACS enriches our fundamental understanding of the pathophysiology of this important manifestation of atherosclerosis. In addition, these insights furnish glimpses into potential novel therapeutic interventions to forestall this ultimate complication of the disease.
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