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10.1016/j.pt.2014.04.005

http://scihub22266oqcxt.onion/10.1016/j.pt.2014.04.005
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C4078766!4078766!24794113
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suck abstract from ncbi


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pmid24794113      Trends+Parasitol 2014 ; 30 (6): 282-8
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  • Genetic shifting: a novel approach for controlling vector-borne diseases #MMPMID24794113
  • Powell JR; Tabachnick WJ
  • Trends Parasitol 2014[Jun]; 30 (6): 282-8 PMID24794113show ga
  • Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticists. We outline a method to achieve this goal that does not involve introduction of any new genetic variants to the target population. Rather we propose that shifting the frequencies of naturally occurring alleles that confer refractoriness to transmission can reduce transmission below a sustainable level. The program employs methods successfully used in plant and animal breeding. Because no artificially constructed genetically modified organisms (GMOs) are introduced into the environment, the method is minimally controversial. We use Aedes aegypti and dengue virus (DENV) for illustrative purposes, but point out the proposed program is generally applicable to vector-borne disease control.
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