Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.tem.2014.04.002 http://scihub22266oqcxt.onion/10.1016/j.tem.2014.04.002 C4077930!4077930!24856037     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Endocrinol+Metab 2014 ; 25 (7): 364-73 Nephropedia Template TP {{tp|p=24856037|t=2014. mTORC2 in the center of cancer metabolic reprogramming |pdf=|usr=}}{{24856037}} gab.com Text mTORC2 in the center of cancer metabolic reprogramming JO: Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24856037 #FOAvip Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Understanding how oncogenes coordinate altered signaling with metabolic reprogramming and global transcription may yield new insights into tumor pathogenesis, and provide a new landscape of promising drug targets, while yielding important clues into mechanisms of resistance to the signal transduction inhibitors currently in use. Here we review the recently identified central regulatory role for mTORC2, a downstream effector of many cancer-causing mutations, in metabolic reprogramming and cancer drug resistance. We consider the impact of mTORC2-related metabolism on epigenetics and therapeutics, with a particular focus on the intractable malignant brain tumor, glioblastoma (GBM). Twit Text FOAVip mTORC2 in the center of cancer metabolic reprogramming ????Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24856037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24856037 #FOAvip English Wikipedia <ref>{{Cite pmid|24856037}}</ref> mTORC2 in the center of cancer metabolic reprogramming #MMPMID24856037 Masui K; Cavenee WK; Mischel PS Trends Endocrinol Metab 2014[Jul]; 25 (7): 364-73 PMID24856037show ga Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Understanding how oncogenes coordinate altered signaling with metabolic reprogramming and global transcription may yield new insights into tumor pathogenesis, and provide a new landscape of promising drug targets, while yielding important clues into mechanisms of resistance to the signal transduction inhibitors currently in use. Here we review the recently identified central regulatory role for mTORC2, a downstream effector of many cancer-causing mutations, in metabolic reprogramming and cancer drug resistance. We consider the impact of mTORC2-related metabolism on epigenetics and therapeutics, with a particular focus on the intractable malignant brain tumor, glioblastoma (GBM). ämTORC2 in the center of cancer metabolic reprogramming (epmc).pdf DeepDyve Pubget Overpricing