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10.1016/j.tig.2014.04.007 http://scihub22266oqcxt.onion/10.1016/j.tig.2014.04.007 C4077918!4077918!24877878     free     free     free       Trends+Genet 2014 ; 30 (7): 271-86 Nephropedia Template TP {{tp|p=24877878|t=2014. Sirtuins: Guardians of Mammalian Healthspan |pdf=|usr=}}{{24877878}} gab.com Text Sirtuins: Guardians of Mammalian Healthspan JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=24877878 #FOAvip The first link between sirtuins and longevity was made 15 years ago in yeast. These initial studies sparked efforts by many laboratories working in diverse model organisms to elucidate the relationships between sirtuins, lifespan, and age-associated dysfunction. Here we discuss the current understanding of how sirtuins relate to aging. We focus primarily on mammalian sirtuins SIRT1, SIRT3, and SIRT6, the three sirtuins for which the most relevant data are available. Strikingly, a large body of evidence now indicates that these and other mammalian sirtuins suppress a variety of age-related pathologies and promote healthspan. Moreover, increased expression of SIRT1 or SIRT6 extends mouse lifespan. Overall, these data point to important roles for sirtuins in promoting mammalian health, and perhaps in modulating the aging process. Twit Text FOAVip Sirtuins: Guardians of Mammalian Healthspan ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=24877878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24877878 #FOAvip English Wikipedia <ref>{{Cite pmid|24877878}}</ref> Sirtuins: Guardians of Mammalian Healthspan #MMPMID24877878 Giblin W; Skinner ME; Lombard DB Trends Genet 2014[Jul]; 30 (7): 271-86 PMID24877878show ga The first link between sirtuins and longevity was made 15 years ago in yeast. These initial studies sparked efforts by many laboratories working in diverse model organisms to elucidate the relationships between sirtuins, lifespan, and age-associated dysfunction. Here we discuss the current understanding of how sirtuins relate to aging. We focus primarily on mammalian sirtuins SIRT1, SIRT3, and SIRT6, the three sirtuins for which the most relevant data are available. Strikingly, a large body of evidence now indicates that these and other mammalian sirtuins suppress a variety of age-related pathologies and promote healthspan. Moreover, increased expression of SIRT1 or SIRT6 extends mouse lifespan. Overall, these data point to important roles for sirtuins in promoting mammalian health, and perhaps in modulating the aging process. äSirtuins: Guardians of Mammalian Healthspan (epmc).pdf DeepDyve Pubget Overpricing