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2014 ; 19
(7
): 735-45
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The challenging world of cytopenias: distinguishing myelodysplastic syndromes
from other disorders of marrow failure
#MMPMID24899643
DeZern AE
; Sekeres MA
Oncologist
2014[Jul]; 19
(7
): 735-45
PMID24899643
show ga
Over the past decade, our understanding of bone marrow failure has advanced
considerably. Marrow failure encompasses multiple overlapping diseases, and there
is increasing availability of diagnostic tools to distinguish among the subtypes.
Identification of genetic alterations that underlie marrow failure has also
greatly expanded, especially for myelodysplastic syndromes. Molecular markers are
increasingly used to guide the management of myelodysplasia and may distinguish
this diagnosis from other marrow failure disorders. This review summarizes the
current state of distinguishing among causes of marrow failure and discusses the
potential uses of multiple diagnostic and prognostic indicators in the management
of myelodysplastic syndromes and other bone marrow failure disorders.