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10.1634/theoncologist.2014-0178 http://scihub22266oqcxt.onion/10.1634/theoncologist.2014-0178 C4077447!4077447!24928612     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncologist 2014 ; 19 (7): 760-5 Nephropedia Template TP {{tp|p=24928612|t=2014. 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy |pdf=|usr=}}{{24928612}} gab.com Text 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy JO: Oncologist http://www.kidney.de/pget.php?&tw=1&pmid=24928612 #FOAvip This review suggests that the full potential of 6-thioguanine (6-TG) in cancer therapy may not have been reached. The authors contrast 6-TG and the more widely used 6-mercaptopurine; discuss 6-TG metabolism, pharmacokinetics, dosage and schedule; and summarize many of the early studies that have shown infrequent but nevertheless positive results with 6-TG treatment. The combination of 6-TG and a natural compound, methylthioadenosine (MTA), may provide selective treatment of cancers that have lost the gene methylthioadenosine phosphorylase (MTAP). Administration of MTA decreases 6-TG toxicity to normal host tissues, thus permitting use of increased therapeutic doses of 6-TG. Combinations of 6-TG with other agents, such as methotrexate or pralatrexate, may also enhance therapeutic effects in MTAP-deficient tumors. Twit Text FOAVip 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy ????Oncologist http://www.kidney.de/pget.php?&tw=1&pmid=24928612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24928612 #FOAvip English Wikipedia <ref>{{Cite pmid|24928612}}</ref> 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy #MMPMID24928612 Munshi PN; Lubin M; Bertino JR Oncologist 2014[Jul]; 19 (7): 760-5 PMID24928612show ga This review suggests that the full potential of 6-thioguanine (6-TG) in cancer therapy may not have been reached. The authors contrast 6-TG and the more widely used 6-mercaptopurine; discuss 6-TG metabolism, pharmacokinetics, dosage and schedule; and summarize many of the early studies that have shown infrequent but nevertheless positive results with 6-TG treatment. The combination of 6-TG and a natural compound, methylthioadenosine (MTA), may provide selective treatment of cancers that have lost the gene methylthioadenosine phosphorylase (MTAP). Administration of MTA decreases 6-TG toxicity to normal host tissues, thus permitting use of increased therapeutic doses of 6-TG. Combinations of 6-TG with other agents, such as methotrexate or pralatrexate, may also enhance therapeutic effects in MTAP-deficient tumors. ä6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy (epmc).pdf DeepDyve Pubget Overpricing