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10.1016/j.ajpath.2014.03.007 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2014.03.007 C4076474!4076474 !24815352     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24815352 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease |pdf=|usr=}}{{24815352 }} gab.com Text Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24815352 #FOAvip In polycystic kidney disease (PKD), renal parenchyma is destroyed by cysts, hypothesized to obstruct nephrons. A signature of unilateral ureteral obstruction, proximal tubular atrophy leads to formation of atubular glomeruli. To determine whether this process occurs in PKD, kidneys from pcy mice (moderately progressive PKD), kidneys from cpk mice (rapidly progressive PKD), and human autosomal dominant PKD were examined in early and late stages. Integrity of the glomerulotubular junction and proximal tubular mass were determined in sections stained with Lotus tetragonolobus lectin. Development of proximal tubular atrophy and atubular glomeruli was determined in serial sections of individual glomeruli. In pcy mice, most glomerulotubular junctions were normal at 20 weeks, but by 30 weeks, 56% were atrophic and 25% of glomeruli were atubular; glomerulotubular junction integrity decreased with increasing cyst area (r = 0.83, P < 0.05). In cpk mice, all glomerulotubular junctions were normal at 10 days, but by 19 days, 26% had become abnormal. In early-stage autosomal dominant PKD kidneys, 50% of glomeruli were atubular or attached to atrophic tubules; in advanced disease, 100% were abnormal. Thus, proximal tubular injury in cystic kidneys closely parallels that observed with ureteral obstruction. These findings support the hypothesis that, in renal cystic disorders, cyst-dependent obstruction of medullary and cortical tubules initiates a process culminating in widespread destruction of proximal convoluted tubules at the glomerulotubular junction. Twit Text FOAVip Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24815352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24815352 #FOAvip English Wikipedia <ref>{{Cite pmid|24815352 }}</ref> Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease #MMPMID24815352 Galarreta CI ; Grantham JJ ; Forbes MS ; Maser RL ; Wallace DP ; Chevalier RL Am J Pathol 2014[Jul]; 184 (7 ): 1957-66 PMID24815352 show ga In polycystic kidney disease (PKD), renal parenchyma is destroyed by cysts, hypothesized to obstruct nephrons. A signature of unilateral ureteral obstruction, proximal tubular atrophy leads to formation of atubular glomeruli. To determine whether this process occurs in PKD, kidneys from pcy mice (moderately progressive PKD), kidneys from cpk mice (rapidly progressive PKD), and human autosomal dominant PKD were examined in early and late stages. Integrity of the glomerulotubular junction and proximal tubular mass were determined in sections stained with Lotus tetragonolobus lectin. Development of proximal tubular atrophy and atubular glomeruli was determined in serial sections of individual glomeruli. In pcy mice, most glomerulotubular junctions were normal at 20 weeks, but by 30 weeks, 56% were atrophic and 25% of glomeruli were atubular; glomerulotubular junction integrity decreased with increasing cyst area (r = 0.83, P < 0.05). In cpk mice, all glomerulotubular junctions were normal at 10 days, but by 19 days, 26% had become abnormal. In early-stage autosomal dominant PKD kidneys, 50% of glomeruli were atubular or attached to atrophic tubules; in advanced disease, 100% were abnormal. Thus, proximal tubular injury in cystic kidneys closely parallels that observed with ureteral obstruction. These findings support the hypothesis that, in renal cystic disorders, cyst-dependent obstruction of medullary and cortical tubules initiates a process culminating in widespread destruction of proximal convoluted tubules at the glomerulotubular junction. |Adult [MESH] |Animals [MESH] |Cysts [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Kidney Glomerulus/*pathology [MESH] |Kidney Tubules, Proximal/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Polycystic Kidney Diseases/*pathology [MESH]Tubular obstruction leads to progressive proximal tubular injury and a(epmc).pdf DeepDyve Pubget Overpricing