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10.1016/j.bbalip.2012.09.004 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2012.09.004 C4076288!4076288!22986288     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2013 ; 1831 (1): 213-22 Nephropedia Template TP {{tp|p=22986288|t=2013. Lysophospholipid receptor activation of RhoA and lipid signaling pathways |pdf=|usr=}}{{22986288}} gab.com Text Lysophospholipid receptor activation of RhoA and lipid signaling pathways JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22986288 #FOAvip The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) signal through G-protein coupled receptors (GPCRs) which couple to multiple G-proteins and their effectors. These GPCRs are quite efficacious in coupling to the G?12/13 family of G-proteins, which stimulate guanine nucleotide exchange factors (GEFs) for RhoA. Activated RhoA subsequently regulates downstream enzymes that transduce signals which affect the actin cytoskeleton, gene expression, cell proliferation and cell survival. Remarkably many of the enzymes regulated downstream of RhoA either use phospholipids as substrates (e.g. phospholipase D, phospholipase C-epsilon, PTEN, PI3 kinase) or are regulated by phospholipid products (e.g. protein kinase D, Akt). Thus lysophospholipids signal from outside of the cell and control phospholipid signaling processes within the cell that they target. Here we review evidence suggesting an integrative role for RhoA in responding to lysophospholipids upregulated in the pathophysiological environment, and in transducing this signal to cellular responses through effects on phospholipid regulatory or phospholipid regulated enzymes. Twit Text FOAVip Lysophospholipid receptor activation of RhoA and lipid signaling pathways ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22986288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22986288 #FOAvip English Wikipedia <ref>{{Cite pmid|22986288}}</ref> Lysophospholipid receptor activation of RhoA and lipid signaling pathways #MMPMID22986288 Xiang SY; Dusaban SS; Brown JH Biochim Biophys Acta 2013[Jan]; 1831 (1): 213-22 PMID22986288show ga The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) signal through G-protein coupled receptors (GPCRs) which couple to multiple G-proteins and their effectors. These GPCRs are quite efficacious in coupling to the G?12/13 family of G-proteins, which stimulate guanine nucleotide exchange factors (GEFs) for RhoA. Activated RhoA subsequently regulates downstream enzymes that transduce signals which affect the actin cytoskeleton, gene expression, cell proliferation and cell survival. Remarkably many of the enzymes regulated downstream of RhoA either use phospholipids as substrates (e.g. phospholipase D, phospholipase C-epsilon, PTEN, PI3 kinase) or are regulated by phospholipid products (e.g. protein kinase D, Akt). Thus lysophospholipids signal from outside of the cell and control phospholipid signaling processes within the cell that they target. Here we review evidence suggesting an integrative role for RhoA in responding to lysophospholipids upregulated in the pathophysiological environment, and in transducing this signal to cellular responses through effects on phospholipid regulatory or phospholipid regulated enzymes. äLysophospholipid receptor activation of RhoA and lipid signaling pathw(epmc).pdf DeepDyve Pubget Overpricing