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10.1194/jlr.M046482 http://scihub22266oqcxt.onion/10.1194/jlr.M046482 C4076075!4076075!24831470     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24831470&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Lipid+Res 2014 ; 55 (7): 1279-87 Nephropedia Template TP {{tp|p=24831470|t=2014. Cideb facilitates the lipidation of chylomicrons in the small intestine |pdf=|usr=}}{{24831470}} gab.com Text Cideb facilitates the lipidation of chylomicrons in the small intestine JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24831470 #FOAvip Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles. Here, we observed that Cideb is expressed in the jejunum and ileum sections of the small intestine, and its expression was induced by high-fat diet. Intragastric gavage with lipids resulted in the retention of lipids in the intestine in Cideb-deficient mice. In addition, we observed that mice with Cideb deficiency exhibited reduced intestinal chylomicron-TG secretion and increased lipid accumulation in the enterocytes. The sizes of chylomicrons secreted from the small intestine of Cideb-deficient mice were also smaller than those from wild-type mice. Furthermore, the overexpression of Cideb increased TG secretion and reduced lipid accumulation in the enterocyte-like Caco-2 cells. In addition, we proved that Cideb was localized to the ER and LDs and could interact with ApoB48 in Caco-2 cells. Overall, these data revealed that Cideb plays an important role in controlling intestinal chylomicron lipidation. Twit Text FOAVip Cideb facilitates the lipidation of chylomicrons in the small intestine ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24831470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24831470 #FOAvip English Wikipedia <ref>{{Cite pmid|24831470}}</ref> Cideb facilitates the lipidation of chylomicrons in the small intestine #MMPMID24831470 Zhang LJ; Wang C; Yuan Y; Wang H; Wu J; Liu F; Li L; Gao X; Zhao YL; Hu PZ; Li P; Ye J J Lipid Res 2014[Jul]; 55 (7): 1279-87 PMID24831470show ga Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles. Here, we observed that Cideb is expressed in the jejunum and ileum sections of the small intestine, and its expression was induced by high-fat diet. Intragastric gavage with lipids resulted in the retention of lipids in the intestine in Cideb-deficient mice. In addition, we observed that mice with Cideb deficiency exhibited reduced intestinal chylomicron-TG secretion and increased lipid accumulation in the enterocytes. The sizes of chylomicrons secreted from the small intestine of Cideb-deficient mice were also smaller than those from wild-type mice. Furthermore, the overexpression of Cideb increased TG secretion and reduced lipid accumulation in the enterocyte-like Caco-2 cells. In addition, we proved that Cideb was localized to the ER and LDs and could interact with ApoB48 in Caco-2 cells. Overall, these data revealed that Cideb plays an important role in controlling intestinal chylomicron lipidation. äCideb facilitates the lipidation of chylomicrons in the small intestin(epmc).pdf DeepDyve Pubget Overpricing