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2014 ; 181
(ä): 1-33
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Lipid peroxidation generates biologically active phospholipids including
oxidatively N-modified phospholipids
#MMPMID24704586
Davies SS
; Guo L
Chem Phys Lipids
2014[Jul]; 181
(ä): 1-33
PMID24704586
show ga
Peroxidation of membranes and lipoproteins converts "inert" phospholipids into a
plethora of oxidatively modified phospholipids (oxPL) that can act as signaling
molecules. In this review, we will discuss four major classes of oxPL: mildly
oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains,
phospholipids with cyclized acyl chains, and phospholipids that have been
oxidatively N-modified on their headgroups by reactive lipid species. For each
class of oxPL we will review the chemical mechanisms of their formation, the
evidence for their formation in biological samples, the biological activities and
signaling pathways associated with them, and the catabolic pathways for their
elimination. We will end by briefly highlighting some of the critical questions
that remain about the role of oxPL in physiology and disease.