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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Radiol
2014 ; 87
(1038
): 20140065
Nephropedia Template TP
gab.com Text
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The use of molecular imaging combined with genomic techniques to understand the
heterogeneity in cancer metastasis
#MMPMID24597512
Chowdhury R
; Ganeshan B
; Irshad S
; Lawler K
; Eisenblätter M
; Milewicz H
; Rodriguez-Justo M
; Miles K
; Ellis P
; Groves A
; Punwani S
; Ng T
Br J Radiol
2014[Jun]; 87
(1038
): 20140065
PMID24597512
show ga
Tumour heterogeneity has, in recent times, come to play a vital role in how we
understand and treat cancers; however, the clinical translation of this has
lagged behind advances in research. Although significant advancements in
oncological management have been made, personalized care remains an elusive goal.
Inter- and intratumour heterogeneity, particularly in the clinical setting, has
been difficult to quantify and therefore to treat. The histological
quantification of heterogeneity of tumours can be a logistical and clinical
challenge. The ability to examine not just the whole tumour but also all the
molecular variations of metastatic disease in a patient is obviously difficult
with current histological techniques. Advances in imaging techniques and novel
applications, alongside our understanding of tumour heterogeneity, have opened up
a plethora of non-invasive biomarker potential to examine tumours, their
heterogeneity and the clinical translation. This review will focus on how various
imaging methods that allow for quantification of metastatic tumour heterogeneity,
along with the potential of developing imaging, integrated with other in vitro
diagnostic approaches such as genomics and exosome analyses, have the potential
role as a non-invasive biomarker for guiding the treatment algorithm.