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10.1016/j.bbr.2014.02.045

http://scihub22266oqcxt.onion/10.1016/j.bbr.2014.02.045
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C4075424!4075424!24613242
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suck abstract from ncbi


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pmid24613242      Behav+Brain+Res 2014 ; 266 (ä): 46-51
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  • Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autism-like stereotypical behaviors in offspring mice #MMPMID24613242
  • Camacho J; Jones K; Miller E; Ariza J; Noctor S; de Water JV; Martínez-Cerdeño V
  • Behav Brain Res 2014[Jun]; 266 (ä): 46-51 PMID24613242show ga
  • Multiple studies have implicated a role of maternal autoantibodies reactive against fetal brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the current study, we examined the impact of brain-reactive maternal autoantibodies of mothers of children with autism (MAU) on offspring behavior in mice compared to offspring exposed to non-reactive IgG of mothers of typically developing children (MTD). Embryonic offspring were exposed to a single intraventricular injection of MAU or MTD IgG on embryonic day 14. Offspring were allowed to mature to adulthood and were subsequently tested for sociability and stereotypic behaviors using a 3-chambered social approach task, marble burying task, and assessment of spontaneous grooming behaviors in response to a novel environment. Results indicate that MAU offspring display autistic-like stereotypic behavior in both marble burying and spontaneous grooming behaviors. Additionally, small alterations in social approach behavior were also observed in MAU offspring compared to MTD offspring. This report demonstrates for the first time the effects of a single, low dose intraventricular exposure of IgG derived from individual MAU samples on offspring behavior.
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