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Embryonic intraventricular exposure to autism-specific maternal autoantibodies
produces alterations in autistic-like stereotypical behaviors in offspring mice
#MMPMID24613242
Camacho J
; Jones K
; Miller E
; Ariza J
; Noctor S
; de Water JV
; Martínez-Cerdeño V
Behav Brain Res
2014[Jun]; 266
(?): 46-51
PMID24613242
show ga
Multiple studies have implicated a role of maternal autoantibodies reactive
against fetal brain proteins specific to autism in the etiology of autism
spectrum disorders (ASD). In the current study, we examined the impact of
brain-reactive maternal autoantibodies of mothers of children with autism (MAU)
on offspring behavior in mice compared to offspring exposed to non-reactive IgG
of mothers of typically developing children (MTD). Embryonic offspring were
exposed to a single intraventricular injection of MAU or MTD IgG on embryonic day
14. Offspring were allowed to mature to adulthood and were subsequently tested
for sociability and stereotypic behaviors using a 3-chambered social approach
task, marble burying task, and assessment of spontaneous grooming behaviors in
response to a novel environment. Results indicate that MAU offspring display
autistic-like stereotypical behavior in both marble burying and spontaneous
grooming behaviors. Additionally, small alterations in social approach behavior
were also observed in MAU offspring compared to MTD offspring. This report
demonstrates for the first time the effects of a single, low dose
intraventricular exposure of IgG derived from individual MAU samples on offspring
behavior.
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