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10.1210/me.2014-1099 http://scihub22266oqcxt.onion/10.1210/me.2014-1099 C4075164!4075164!24825400     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Endocrinol 2014 ; 28 (7): 1012-25 Nephropedia Template TP {{tp|p=24825400|t=2014. Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation |pdf=|usr=}}{{24825400}} gab.com Text Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation JO: Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=24825400 #FOAvip GH exerts a diverse array of physiological actions that include prominent roles in growth and metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects by influencing gene expression profiles, and Igf1 is a key transcriptional target of GH signaling in liver and other tissues. This review examines the mechanisms of GH-mediated gene regulation that begin with signal transduction pathways activated downstream of the GH receptor and continue with chromatin events at target genes and additionally encompasses the topics of negative regulation and cross talk with other cellular inputs. The transcription factor, signal transducer and activator of transcription 5b, is regarded as the major signaling pathway by which GH achieves its physiological effects, including in stimulating Igf1 gene transcription in liver. Recent studies exploring the mechanisms of how activated signal transducer and activator of transcription 5b accomplishes this are highlighted, which begin to characterize epigenetic features at regulatory domains of the Igf1 locus. Further research in this field offers promise to better understand the GH-IGF-1 axis in normal physiology and disease and to identify strategies to manipulate the axis to improve human health. Twit Text FOAVip Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation ????Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=24825400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24825400 #FOAvip English Wikipedia <ref>{{Cite pmid|24825400}}</ref> Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation #MMPMID24825400 Chia DJ Mol Endocrinol 2014[Jul]; 28 (7): 1012-25 PMID24825400show ga GH exerts a diverse array of physiological actions that include prominent roles in growth and metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects by influencing gene expression profiles, and Igf1 is a key transcriptional target of GH signaling in liver and other tissues. This review examines the mechanisms of GH-mediated gene regulation that begin with signal transduction pathways activated downstream of the GH receptor and continue with chromatin events at target genes and additionally encompasses the topics of negative regulation and cross talk with other cellular inputs. The transcription factor, signal transducer and activator of transcription 5b, is regarded as the major signaling pathway by which GH achieves its physiological effects, including in stimulating Igf1 gene transcription in liver. Recent studies exploring the mechanisms of how activated signal transducer and activator of transcription 5b accomplishes this are highlighted, which begin to characterize epigenetic features at regulatory domains of the Igf1 locus. Further research in this field offers promise to better understand the GH-IGF-1 axis in normal physiology and disease and to identify strategies to manipulate the axis to improve human health. äMinireview: Mechanisms of Growth Hormone-Mediated Gene Regulation (epmc).pdf DeepDyve Pubget Overpricing